1,2,4-oxadiazole-5-imine derivative and synthesis method thereof
A technology for oxadiazoles and derivatives, which is applied in the field of 1,2,4-oxadiazole-5-imine derivatives and their synthesis, can solve the problems of cumbersome post-processing, rare products containing chiral structures, and limitations Application range and other issues, to achieve the effect of high selectivity and yield, good industrial application prospects
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[0027] Example 1
[0028] Synthesis of 2-methyl-N,3,4-triphenyl-1,2,4-oxadiazole-5-imine
[0029] Add 1.5mmol of N-methyl-1-phenylcarbodiimide oxide to the reaction vessel, then add 2ml of acetonitrile, 0.10mmol of diphenylcarbodiimide compound, and react at 60°C. After the reaction, use the aqueous solution After washing, extraction with organic solvent, drying, vacuum distillation and concentration to remove the solvent, the crude product is separated by column chromatography to obtain the target product with a yield of 92%.
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[0030] Example 2
[0031] Synthesis of 2-methyl-N,4-diphenyl-3-(o-tolyl)-1,2,4-oxadiazole-5-imine
[0032] Add 1.5mmol of N-methyl-1-o-tolylcarbodiimide oxide in the reaction vessel, then add 2ml of acetonitrile, 0.10mmol of diphenylcarbodiimide compounds, and react at 60°C. After the reaction, use The aqueous solution is washed, then extracted with an organic solvent, dried, and concentrated under reduced pressure to remove the solvent. The crude product is separated by column chromatography to obtain the target product with a yield of 86%.
Example Embodiment
[0033] Example 3
[0034] Synthesis of 2-methyl-N,4-diphenyl-3-(p-tolyl)-1,2,4-oxadiazole-5-imine
[0035] Add 1.5mmol of N-methyl-1-p-tolylcarbodiimide oxide in the reaction vessel, then add 2ml of acetonitrile, 0.10mmol of diphenylcarbodiimide compounds, and react at 60°C. After the reaction is over, use The aqueous solution is washed, then extracted with an organic solvent, dried, and concentrated under reduced pressure to remove the solvent. The crude product is separated by column chromatography to obtain the target product with a yield of 90%.
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