6 results about "Para-nitrophenyl" patented technology

The present invention relates to a galantamine analog having a cholinesterase inhibitory activity, and a preparation method therefor and the use thereof. The galantamine analog has a general structural formula as shown in formula (IA), (IB) or (IC). In formula (IA), R1 is selected from hydrogen, o-fluoro, m-fluoro, p-fluoro, 2,4-difluoro, m-trifluoromethyl, p-methyl, 3,5-dimethoxy, p-chloro, p-nitro, p-cyano or p-trifluoromethoxy. In formula (IB), R2 is selected from phenyl, o-fluorophenyl, m-fluorophenyl, p-fluorophenyl, 2,4-difluorophenyl, 3,5-difluorophenyl, o-methylphenyl, p-methylphenyl, p-methoxyphenyl, indole, p-cyanophenyl, p-trifluoromethylphenyl, p-trifluoromethoxyphenyl, p-nitrophenyl or naphthalene ring. In formula (IC), R3 is selected from hydrogen, o-fluoro, m-fluoro, p-fluoro, m-chloro, p-chloro, p-methyl, o-methoxy, m-methoxy or p-methoxy. The galantamine analog of the present invention has a cholinesterase inhibitory activity superior to that of galantamine, and is expected to be used for treating diseases associated with cholinergic dysfunction.

This invention relates to a galantamine analogue with cholinesterase-inhibiting activity, its preparation method, and its application. The general structural formula is shown in formula (IA), (IB), or (IC). In formula (IA), R1 is selected from hydrogen, o-fluorine, m-fluorine, p-fluorine, 2,4-difluoro, m-trifluoromethyl, p-methyl, 3,5-dimethoxy, p-chloro, p-nitro, p-cyano, or p-trifluoromethoxy. In formula (IB), R2 is selected from phenyl, o-fluorophenyl, m-fluorophenyl, p-fluorophenyl, 2,4-difluorophenyl, 3,5-difluorophenyl, o-methylphenyl, p-methylphenyl, p-methoxyphenyl, indole, p-cyanophenyl, p-trifluoromethylphenyl, p-trifluoromethoxyphenyl, p-nitrophenyl, or a naphthalene ring. In formula (IC), R3 is selected from hydrogen, o-fluorine, m-fluorine, p-fluorine, m-chloro, p-chloro, p-methyl, o-methoxy, m-methoxy, or p-methoxy. The galantamine analogue of this invention exhibits superior inhibitory activity against cholinesterase compared to galantamine, and holds promise for the treatment of cholinergic dysfunction-related diseases.

This invention relates to a galantamine analogue with cholinesterase-inhibiting activity, its preparation method, and its application. The general structural formula is shown in formula (IA), (IB), or (IC). In formula (IA), R1 is selected from hydrogen, o-fluorine, m-fluorine, p-fluorine, 2,4-difluoro, m-trifluoromethyl, p-methyl, 3,5-dimethoxy, p-chloro, p-nitro, p-cyano, or p-trifluoromethoxy. In formula (IB), R2 is selected from phenyl, o-fluorine, m-fluorine, p-fluorine, 2,4-difluorophenyl, 3,5-difluorophenyl, o-methylphenyl, p-methylphenyl, p-methoxyphenyl, indole, p-cyanophenyl, p-trifluoromethylphenyl, p-trifluoromethoxyphenyl, p-nitrophenyl, or a naphthalene ring. In formula (IC), R3 is selected from hydrogen, o-fluorine, m-fluorine, p-fluorine, m-chloro, p-chloro, p-methyl, o-methoxy, m-methoxy, or p-methoxy. The galantamine analogue of this invention has superior inhibitory activity against cholinesterase compared to galantamine, and is expected to be used to treat cholinergic dysfunction-related diseases.

The invention relates to oligomeric urea-amine molecules, preparation and application in carbon dioxide adsorption, and belongs to the technical field of high polymer materials. The preparation method comprises the following steps: firstly, reacting an amino-containing compound with p-nitrophenyl chloroformate to generate carbamate with a specific structure, and then reacting carbamate with hydrazine hydrate to combine amine groups in carbamate with hydrazine molecules in hydrazine hydrate to obtain oligomeric urea-amine molecules. The molecule has the characteristics of simple structure, excellent water solubility and high melting point, and can efficiently adsorb carbon dioxide; and after heating treatment at a relatively low temperature, desorption release of carbon dioxide can be realized, and regeneration of molecules can also be achieved.

The application relates to a nitro catalytic hydrogenation sulfur-resistant catalyst and a preparation method and application thereof, and belongs to the technical field of nickel-based catalyst preparation. The catalyst is prepared by adopting a deposition precipitation method and takes nickel as an active component, adds a certain amount of molybdenum additives and takes diatomite as a carrier; the catalyst is suitable for a catalytic hydrogenation production process of a p-nitrophenyl-beta-hydroxyethyl sulfone or m-nitrophenyl-beta-hydroxyethyl sulfone. The catalyst can be recycled and applied for multiple times while maintaining high activity and high selectivity, the efficiency of the catalyst is improved with the increase of the molybdenum content, and the catalyst can be recycled and applied for multiple times, which shows that the addition of molybdenum is beneficial to the sulfur resistance of the catalyst. The catalyst has the characteristics of high catalytic activity, good stability and easy separation; compared with a traditional Raney nickel catalyst, the catalyst can still maintain high activity after being used for multiple times, and has important significance for realizing the nitro catalytic hydrogenation sulfur resistance.

This invention relates to the field of coating technology, specifically to a coating containing a novel ultraviolet absorber and its preparation method. The raw materials of this coating, by weight, include 45–55 parts of aliphatic polyurethane diacrylate, 22–28 parts of isobornyl acrylate, 12–18 parts of 1,6-hexanediol diacrylate, 2.5–3.5 parts of the novel ultraviolet absorber, 1.6–2.4 parts of photoinitiator 1173, 0.8–1.2 parts of photoinitiator TPO, and 36–44 parts of propylene glycol methyl ether acetate. The absorber is obtained by activating the triazine-phenol structure with p-nitrophenyl chlorocarbonate and coupling it with 6-amino-6-deoxy-β-cyclodextrin, followed by epoxidation, amphoteric segment grafting, and methacrylamide, thereby achieving site immobilization, amphoteric regulation, and polymerizable anchoring of the ultraviolet absorption unit. The resulting coating exhibits excellent adhesion, hardness, and bending resistance on low surface energy films, high ultraviolet shielding efficiency, and long-term weather stability, making it suitable for outdoor protective coating applications.