32 results about "ENDOGLYCAN" patented technology

Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM197.

Disclosed are hybrid genes of glucanase and dextransucrase, recombinant vectors comprising said hybrid genes, microorganisms which are transformed with said recombinant vectors, hybrid enzymes which are expressed from said hybrid genes, and processes for preparing isomalto-oligosaccharides or dextran using said microorganisms or enzymes. Expensive isomalto-oligosaccharides and low molecular weight dextran for clinical use can be produced simply and effectively from cheap substrate-sucrose, using a single bacterial strain or enzyme.

The invention discloses a pollen natto tablet, which comprises the following components in parts by weight: 4-5 parts of pollen, 3-4 parts of natto, 1-2 parts of anka and 1-2 parts of oligosaccharide. The pollen uses bee pollen as a raw material. The method for preparing the pollen comprises the following steps: firstly sprying the raw material bee pollen with 50-100PPM ClO2 aqueous solution; sterilizing for 30 minutes in a closed manner; adjusting humidity to 25%; then inoculating ferments to ferment at the temperature of 30-37 DEG C for 12 hours; and verifying acidity, cryodrying to obtain the pollen when the PH value is 4.5. The pollen natto tablet of the invention generates secondary products such as multiple enzymes, lactic acid, vitamin and the like after the raw material is fermented with beneficial bacterium, and combines the health care functions of the raw material and beneficial microorganisms, therefore the pollen natto tablet can supply human body with balanced nutrition, adjust human body endocrine metabolism, promote recovery of certain diseases, and improve human sub-health state.

The present invention relates to pharmaceutical compositions containing tumor-selective targeted inhibitor glycoconjugates. These bioconjugates are ALK5 inhibitors covalently bound to biocompatible carrier molecules which selectively target and specifically bind to Muc4 that is overexpressed on a variety of tumor cell types. The ALK5 inhibitors are conjugated to tumor targetable glycans through a covalent linker. Preferably the acid-labile linker is designed to be stable in plasma and releases pharmacologically active inhibitors through acid-catalyzed hydrolysis in the acidic environment of the target tumor where the inhibitor activity is restored. Because the glycoconjugates are stable at physiological pH and in plasma, they advantageously reduce undesirable systemic ALK5 inhibitor activity; however, the preferable glycoconjugates are acid-labile conjugates that can be hydrolyzed upon reaching the more acid environment of the tumor.

The invention discloses an active composition containing copper peptide and a cosmetic or skin care product. The active composition containing copper peptide is prepared from the following components in percentage by weight: 0.001-2 percent of copper peptide, 1-5 percent of vitamin E, 0.1-10 percent of chitin oligosaccharide, 0.1-2 percent of 4-MSK, 0.1-5 percent of algal polysaccharides, 6-30 percent of emulsifier, 0-10 percent of co-emulsifier, 0.1-0.8 percent of stabilizer, 0-10 percent of excipient and the balance of water. The active composition and the cosmetic or skin care product have the effects of promoting cell reproduction, remarkably moisturizing and moistening, delaying senescence and the like.