Analogue of thalidomide and preparation method

A technology of thalidomide and its analogues, which can be applied in drug combinations, bone diseases, non-central analgesics, etc., and can solve problems such as fatigue and constipation
CN1696127AInactive Publication Date: 2005-11-16CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2005-11-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

A novel analog of thalidomide and its preparing process are disclosed.
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Description

technical field

[0001] The present invention relates to a series of analogues of thalidomide and their preparation methods. Background technique

[0002] Thalidomide, also known as Thalidomide, is a drug marketed in the late 1950s, used for sedation, hypnosis and antiemetic in early pregnancy. But it was soon discovered that the drug had serious teratogenic effects on the fetus. The drug was withdrawn from the market in the early 1960s. In 1965, Israeli doctor Sheskin (Sheskin, J. Clin Pharmacol. Ther. 1965, 6: 303-306) reported that thalidomide could effectively treat erythematous nodular leprosy (ENL). In 1998, FDA (US Food and Drug Administration) approved thalidomide for the treatment of ENL. In my country, thalidomide is the national essential drug for the treatment of leprosy concomitant diseases. In addition to treating ENL, thalidomide has currently known biological activities including immunosuppression, anti-cancer, and anti-HIV-1 virus. The research on thalid...

Claims

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