Lysine-based polyesteramide nano drug delivery system as well as preparation method and application thereof

A technology of polyester amide and lysine, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. It can solve the problems of being unable to entrap drugs in nanoparticles and achieve good biosafety Sexuality, efficient and controllable release, enhanced utilization effect
CN110804177AActive Publication Date: 2020-02-18SUN YAT SEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUN YAT SEN UNIV
Publication Date
2020-02-18

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Abstract

The invention discloses a lysine-based polyesteramide nano drug delivery system as well as a preparation method and application thereof. The preparation method of the polyesteramide polymer includes the following steps: synthesizing a dicarboxylic acid di-p-nitrophenyl ester monomer; synthesizing a di-lysine di-p-toluenesulfonate ester monomer; and adding the dicarboxylic acid di-p-nitrophenyl ester monomer and the di-lysine di-p-toluenesulfonate ester monomer according to a mass ratio of equal to or less than 1:1 into a reaction solvent, adding triethylamine dropwise under stirring at 65-85 DEG C as a reaction catalyst, and performing a heating reaction at 60-80 DEG C for 24-96 h to obtain the polyesteramide polymer with good water solubility. The polyesteramide polymer can efficiently load and deliver and controllably release water-soluble protein drugs, has good biosecurity and drug release, and significantly improves the stability and bioavailability of the protein drugs in a systemic circulation.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical materials. More specifically, it relates to a lysine-based polyester amide nano drug delivery system suitable for high-efficiency loading delivery and controlled release of water-soluble protein drugs, as well as its preparation method and application. Background technique

[0002] Diabetes mellitus is a metabolic disease that causes hyperglycemia due to impaired blood glucose regulation mechanisms in the body. my country is one of the countries with the fastest growing prevalence of diabetes. Long-term high blood sugar levels in diabetic patients will lead to many complications such as chronic damage and dysfunction of the eyes, kidneys, and heart, which greatly increases the risk of blindness, kidney failure, heart disease, and stroke. seriously affect the quality of life. The formation of long-term hyperglycemia is mainly caused by defects in insulin secretion (absolute lack of insulin), ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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