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Polymer hydrogel based on Fe3+-dopamine modification and preparing method thereof

A polymer and dopamine technology, applied in the field of multifunctional polymer materials, can solve the problems of poor mechanical properties of Pluronis hydrogels, and achieve the effects of easy operation, simple method, and pH-responsive self-healing

Active Publication Date: 2016-12-14
SANMING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a physical hydrogel, Pluronis hydrogel has poor mechanical properties, resulting in rapid drug release under physiological conditions.

Method used

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  • Polymer hydrogel based on Fe3+-dopamine modification and preparing method thereof
  • Polymer hydrogel based on Fe3+-dopamine modification and preparing method thereof
  • Polymer hydrogel based on Fe3+-dopamine modification and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] PluF127-DOPA-Fe 3+ Preparation of hydrogel:

[0028] (1) Weigh 0.9675g of p-nitrophenyl chlorate accurately and place it in a 250ml round bottom flask, add 10ml of anhydrous dichloromethane and stir to dissolve; dissolve 10g of hydroxyl-containing polymer Pluronic F127 in 60ml of dichloromethane In the methane solvent, add 245.5μL of triethylamine. Under stirring and nitrogen protection, add the mixture dropwise to the methylene chloride solution with p-nitrophenyl chlorate; after the addition is complete, the mixed solution After stirring for 48 hours at 22°C, extract once with saturated NaCl solution, collect the organic phase, and dry the organic phase with anhydrous sodium sulfate for 30 minutes, then filter and concentrate; drop the concentrated solution into anhydrous ether at 0°C , Get white precipitate; filter, vacuum dry; repeat the above titration precipitation twice to obtain purified p-nitrophenyl chlorate activated polymer PlF127- p -NPC;

[0029] The coupling ...

Embodiment 2

[0051] PluF68-DOPA-Fe 3+ Preparation of hydrogel:

[0052] (1) Accurately weigh 1.6900g of p-nitrophenyl chlorate into a 250ml round bottom flask, add 12ml of anhydrous dichloromethane and stir to dissolve; Dissolve 12g of hydroxyl-containing polymer Pluronic F68 in 60ml of dichloromethane In the methane solvent, add 368μL of triethylamine. Under stirring and nitrogen protection, add the mixture dropwise to the methylene chloride solution dissolved with p-nitrophenyl chlorate; after the addition, the mixed solution is After stirring for 48 hours at 30°C, it was extracted once with saturated NaCl solution. The organic phase was collected and dried with anhydrous sodium sulfate for 30 minutes, filtered and concentrated by suction; the concentrated solution was dropped into anhydrous ether at 4°C, Obtain a white precipitate; filter and vacuum dry; repeat the above-mentioned titration and precipitation twice to obtain purified p-nitrophenyl chlorate activated polymer PlF68- p -NPC;

...

Embodiment 3

[0058] PEG10000-DOPA-Fe 3+ Preparation of hydrogel:

[0059] (1) Accurately weigh 2.4188g of p-nitrophenyl chlorate into a 250ml round bottom flask, add 20ml of anhydrous dichloromethane and stir to dissolve; dissolve 20g of hydroxyl-containing polymer polyethylene glycol 10000 (PEG10000) In 100mL of dichloromethane solvent, add 613.6μL of triethylamine, under stirring and nitrogen protection, add this mixture dropwise to the dichloromethane solution dissolved with p-nitrophenyl chlorate; After completion, the mixed solution was stirred at 26°C for 48 hours, and then extracted once with saturated NaCl solution. The organic phase was collected and dried with anhydrous sodium sulfate for 30 minutes, filtered and concentrated by suction; the concentrated solution was dropped to 2°C In the anhydrous ether, a white precipitate is obtained; filtered and dried in vacuum; repeat the above titration and precipitation twice to obtain purified p-nitrophenyl chlorate activated polymer PEG100...

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Abstract

The invention discloses polymer hydrogel based on Fe3+-dopamine modification and a preparing method thereof. Polymer containing a hydroxyl group is used as a main raw material, dopamine is selected as a functional group, and p-nitrophenyl chlorate is used as an activating agent and directly reacts with dopamine hydrochloride to prepare the polymer with the terminal modified by dopamine; coordination of the polymer with the terminal modified by dopamine and Fe3+ through pH adjustment is achieved. The hydrogel has adhesiveness, thermosensitivity, pH responsiveness, self-healing and other multifunctional characteristics and has potential application value in biomedical engineering and underwater mechanical coatings.

Description

Technical field [0001] The invention belongs to the field of multifunctional polymer materials, and specifically relates to an Fe-based 3+ -Dopamine modified polymer hydrogel and its preparation method. Background technique [0002] Hydrogel is a hydrophilic polymer with a three-dimensional network structure formed by cross-linking through covalent or non-covalent bonds. Because it has very similar physical properties to human soft tissue, it has application value in the fields of sensors, separation systems, and biomedical materials. In the past ten years, stimulus-responsive hydrogels have attracted widespread attention due to their external field response to environmental stimuli. The morphology and performance of this type of hydrogel can vary with the external environment such as pH, temperature, light, and chemical substances. Since stimulus responsiveness is one of the basic functions of biology, this type of environmentally sensitive hydrogel has a wide range of applica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G65/323C08G65/333C08G65/337C08J3/075
CPCC08G65/323C08G65/33396C08G65/337C08J3/075C08J2371/02
Inventor 黄葵肖旺钏苏志忠
Owner SANMING UNIV
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