Polymer hydrogel modified based on fe3+-dopamine and its preparation method

A polymer and dopamine technology, applied in the field of multifunctional polymer materials, can solve the problems of poor mechanical properties of Pluronis hydrogel, and achieve the effect of easy operation, pH responsive self-healing, and simple method

Active Publication Date: 2018-06-08
SANMING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a physical hydrogel, Pluronis hydrogel has poor mechanical properties, resulting in rapid drug release under physiological conditions.

Method used

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  • Polymer hydrogel modified based on fe3+-dopamine and its preparation method
  • Polymer hydrogel modified based on fe3+-dopamine and its preparation method
  • Polymer hydrogel modified based on fe3+-dopamine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] PluF127-DOPA-Fe 3+ Preparation of hydrogel:

[0028] (1) Accurately weigh 0.9675g of p-nitrophenyl chlorate into a 250ml round bottom flask, add 10ml of anhydrous dichloromethane and stir to dissolve; dissolve 10g of hydroxyl-containing polymer Pluronic F127 in 60 mL of dichloromethane Add 245.5 μL of triethylamine to the methane solvent, and add the mixed solution dropwise into the methylene chloride solution dissolved with p-nitrophenyl chlorate under stirring and nitrogen protection; after the dropwise addition, mix the solution After stirring at 22°C for 48 hours, extract once with saturated NaCl solution, collect the organic phase, and dry the organic phase with anhydrous sodium sulfate for 30 min, filter it with suction and concentrate; drop the concentrated solution into anhydrous diethyl ether at 0°C , a white precipitate was obtained; filtered and dried in vacuo; the above titration and precipitation were repeated twice to obtain the purified p-nitrophenyl chl...

Embodiment 2

[0051] PluF68-DOPA-Fe 3+ Preparation of hydrogel:

[0052] (1) Accurately weigh 1.6900g of p-nitrophenyl chlorate into a 250ml round bottom flask, add 12ml of anhydrous dichloromethane and stir to dissolve; dissolve 12g of hydroxyl-containing polymer Pluronic F68 in 60 mL of dichloromethane Add 368 μL of triethylamine to the methane solvent, and add the mixed solution dropwise into the dichloromethane solution dissolved with p-nitrophenyl chlorate under stirring and nitrogen protection; after the dropwise addition, the mixed solution is After stirring at 30°C for 48 hours, extract once with saturated NaCl solution, collect the organic phase, and dry the organic phase with anhydrous sodium sulfate for 30 min, then filter with suction and concentrate; drop the concentrated solution into anhydrous diethyl ether at 4°C, Obtain a white precipitate; filter and dry in vacuo; repeat the above titration and precipitation twice to obtain the purified p-nitrophenyl chlorate-activated poly...

Embodiment 3

[0058] PEG10000-DOPA-Fe 3+ Preparation of hydrogel:

[0059] (1) Accurately weigh 2.4188g of p-nitrophenyl chlorate into a 250ml round bottom flask, add 20ml of anhydrous dichloromethane and stir to dissolve; dissolve 20g of hydroxyl-containing polymer polyethylene glycol 10000 (PEG10000) In 100mL of dichloromethane solvent, add 613.6μL of triethylamine, under stirring and nitrogen protection, add the mixed solution dropwise to the dichloromethane solution in which p-nitrophenyl chlorate is dissolved; dropwise After completion, the mixed solution was stirred at 26°C for 48 hours, extracted once with a saturated NaCl solution, collected the organic phase, and dried the organic phase with anhydrous sodium sulfate for 30 minutes, then suction filtered and concentrated; the concentrated solution was dropped to 2°C In anhydrous ether, a white precipitate was obtained; filtered and vacuum-dried; the above titration and precipitation were repeated twice to obtain the purified p-nitr...

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Abstract

The invention discloses polymer hydrogel based on Fe3+-dopamine modification and a preparing method thereof. Polymer containing a hydroxyl group is used as a main raw material, dopamine is selected as a functional group, and p-nitrophenyl chlorate is used as an activating agent and directly reacts with dopamine hydrochloride to prepare the polymer with the terminal modified by dopamine; coordination of the polymer with the terminal modified by dopamine and Fe3+ through pH adjustment is achieved. The hydrogel has adhesiveness, thermosensitivity, pH responsiveness, self-healing and other multifunctional characteristics and has potential application value in biomedical engineering and underwater mechanical coatings.

Description

technical field [0001] The invention belongs to the field of multifunctional polymer materials, in particular to a Fe-based 3+ - Dopamine-modified polymer hydrogels and methods for their preparation. Background technique [0002] Hydrogel is a hydrophilic polymer with a three-dimensional network structure formed by cross-linking through covalent or non-covalent bonds. Because it has very similar physical properties to human soft tissue, it has application value in the fields of sensors, separation systems and biomedical materials. In the last ten years, stimuli-responsive hydrogels have attracted widespread attention due to their external field response to environmental stimuli. The morphology and performance of this type of hydrogel can change with changes in the external environment such as pH value, temperature, light and chemical substances. Since stimuli responsiveness is one of the basic biological functions, such environmentally sensitive hydrogels have a wide rang...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G65/323C08G65/333C08G65/337C08J3/075
CPCC08G65/323C08G65/33396C08G65/337C08J3/075C08J2371/02
Inventor 黄葵肖旺钏苏志忠
Owner SANMING UNIV
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