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Image processing method for positioning centromere according to feature extraction algorithm

A feature extraction and image processing technology, applied in the field of image processing, can solve the problem of inaccurate centromere position, and achieve the effect of high accuracy and large number of samples

Active Publication Date: 2020-05-29
HUNAN ZIXING INTELLIGENT MEDICAL TECH CO LTD
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Problems solved by technology

[0004] Therefore, the range of the centromere is taken in the present invention in order to be able to find the position of the centromere automatically, and the range of the chromosome position must be determined because the centromere has a lot of noise and many other factors will cause the centromere position found to be insufficient precise

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  • Image processing method for positioning centromere according to feature extraction algorithm
  • Image processing method for positioning centromere according to feature extraction algorithm
  • Image processing method for positioning centromere according to feature extraction algorithm

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Embodiment Construction

[0064] In order to describe the invention more specifically, the invention is divided into two parts. The first part is the selection of the centromere segment of the chromosome, and the determination of the centromere segment is realized through the following two parts of data processing. The second part is the positioning of the centromere position. According to the chromosome without satellite and with satellite, two chromosome images have been taken as examples to illustrate the algorithm in the present invention. Flow process of the present invention is attached image 3 As shown, centromere positioning is achieved through the following 4 partial data processing.

[0065] Chromosome selection of centromere segment

[0066] Step 1. Screening chromosomes: Screen out about 600 samples from each chromosome number: a. Remove and screen out chromosomes with missing information or very curved chromosomes; b. According to the centromere of each chromosome of each number Grain p...

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Abstract

The invention discloses an image processing method for positioning centromere according to a feature extraction algorithm. The image processing method comprises the following steps: extracting the range of the centromere by taking the centromere position of each chromosome of each number as sample data; then, after range selection of each chromosome is counted, processing chromosome images throughtechnologies of feature extraction, denoising, image preprocessing, image segmentation and the like according to each chromosome to accurately locate the range of centromere, solving the normal of each chromosome in the range, and enabling the position where the shortest normal is located to be the position where the centromere is located. The accuracy of the chromosomes 1-22 and the X chromosomein the test reaches 99% or above, the accuracy of the Y chromosome reaches 98% or above, and the data of each chromosome is at least 500.

Description

technical field [0001] The invention relates to an image processing method for locating a centromere according to a feature extraction algorithm, and belongs to the field of image processing. Background technique [0002] Chromosomal karyotype analysis plays a vital role in the detection of genetic diseases. Most of the genetic diseases are chromosomal abnormalities, and many chromosomal abnormalities will cause changes in the position of the centromere, so many genetic diseases can be judged based on the abnormal position of the centromere. [0003] Everyone has 46 chromosomes, 22 pairs of chromosomes and a pair of sex chromosomes. Among the homologous chromosomes, chromosomes 1 to 22 show a process of getting smaller and smaller. The size of sex chromosome X is the same as that of chromosomes 7 and 8. Chromosomes are of similar size while Y chromosomes vary in size (see attached figure 1 And attached figure 2 shown), and the centromere has a wide range of positions (as...

Claims

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Application Information

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IPC IPC(8): G06K9/00G06K9/38G06K9/40
CPCG06V20/695G06V10/28G06V10/30
Inventor 石慧娟张娟刘丽珏李仪穆阳
Owner HUNAN ZIXING INTELLIGENT MEDICAL TECH CO LTD
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