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In any given asexually reproducing species, the chromosome number is always the same. In sexually reproducing organisms, the number of chromosomes in the body (somatic) cells typically is diploid (2n; a pair of each chromosome), twice the haploid (1n) number found in the sex cells, or gametes.
A detection system, device and method for analyzing embryo chromosomal aneuploidy and parental contamination
ActiveCN117238375BReference databaseGenetic linkage disequilibrium
The application discloses a detection system, device and method for embryo chromosomal aneuploidy and parent contamination analysis. The system comprises a database module, an alignment module, an analysis and calculation module and a parent contamination detection module. The analysis and calculation module is used for performing the following steps: calculating the ratio of the number of effective sequences matched to each chromosome to the number of corresponding chromosome sequences in the reference database, performing statistical analysis, obtaining the number of target chromosomes of the sample to be detected, and obtaining the detection result of whether the frequency of alleles observed in the genetic linkage disequilibrium mode is abnormal. The parent contamination detection module comprises a contamination prediction model. The aneuploidy detection and parent contamination analysis of the embryo can be simultaneously realized by one detection.
Owner:SUZHOU BASECARE MEDICAL DEVICE CO LTD