Novel biflavone compound as well as preparation method and application thereof

A technology of biflavonoids and compounds, applied in the field of natural medicinal chemistry

Active Publication Date: 2020-06-05
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the structure of the biflavone compound has certain novelty, and there are no related reports on GPR35 agonist compounds with similar structures

Method used

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  • Novel biflavone compound as well as preparation method and application thereof
  • Novel biflavone compound as well as preparation method and application thereof
  • Novel biflavone compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0043] The following examples are intended to illustrate the present invention rather than to further limit the present invention, and the present invention can be implemented according to any mode described in the summary of the present invention.

[0044] The preparation embodiment of formula (I) compound of the present invention:

[0045] compound preparation

[0046] Taihang Thuja medicinal material 50 kg, provided by Hebei Yunjing Biotechnology Co., Ltd.

[0047] (1) Medicinal material extraction: Taihang Thuja shaving-like medicinal material 5kg, add 10L of pure water for each kilogram of medicinal material, heat and reflux at 90°C for 1.5 hours, filter while hot, repeat extraction once again, filter while hot, and combine the filtrates twice to obtain Concentrate;

[0048] (2) Use the reverse phase preparation column (C18YE packing, 60um) to roughly separate the concentrated solution obtained in step (1), and wash it with ethanol-water at a volume ratio of 10:90, 60:4...

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PUM

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Abstract

The invention relates to novel biflavone compound Yunjingsu as well as application and a preparation method thereof, and a biological activity experiment shows that the biflavone compound has GPR35 agonistic activity and can be used in medicines for preventing and treating diseases such as hypertension, asthma, pain, inflammation and tumors related to GPR35 receptors.

Description

technical field [0001] The present invention belongs to the field of natural medicinal chemistry, and more specifically relates to a new biflavone compound icelin and its preparation method and as a GRR35 agonist active ingredient for treating related diseases such as diabetes, heart failure, hypertension, and coronary artery disease , asthma, pain, early onset inflammatory disease, inflammation, and cancer Background technique [0002] Flavonoids are plant secondary metabolites, which widely exist in natural plants and play an important role in plant growth, development, flowering, fruiting, antibacterial and disease prevention. It mainly exists in the free state or in the form of glycoside combined with sugar. It not only has a large number and variety, but also has a complex and diverse structure type, showing a variety of pharmacological activities. It can prevent and treat cardiovascular and cerebrovascular diseases and respiratory system diseases, and has pharmacologi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/32C07D311/40A61K31/352A61P29/00A61P35/00A61P3/10A61P9/12A61P9/04A61P11/06A61P1/16
CPCC07D311/32C07D311/40A61P29/00A61P35/00A61P3/10A61P9/12A61P9/04A61P11/06A61P1/16
Inventor 梁鑫淼魏红丽金红利刘艳芳侯滔王纪霞钮蕊
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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