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Solid composition comprising iron for use in iron deficient conditions

A solid composition, the technology of the composition, applied in the directions of drug combination, active ingredient of phosphorus compound, metabolic diseases, etc., can solve the problems of reduced bioavailability, reduced absorption, and reduced absorption of ferrous or iron ions

Pending Publication Date: 2020-06-12
ALESCO SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral iron intake can lead to constipation and epigastric pain, necessitating the administration of iron-based compositions under fed conditions, with the inevitable result of severely reduced absorption
[0007] A second limitation is that the tolerability of orally administered iron salts (particularly ferrous sulfate) is characterized by recurrent gastrointestinal (GI) side effects, which in several cases limits their use
[0008] A third limitation is that currently commercially available iron salt formulations have reduced bioavailability
[0009] Therefore, in addition to the reduced absorption of iron (iron(II) or iron(III)) salts, there is also the problem of reduced bioavailability of ferrous or ferric ions themselves

Method used

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Embodiment Construction

[0025] Preferred embodiments of the present invention will be more apparent from the following detailed description.

[0026] The compositions of the present invention are solid compositions. Solid state means that the composition of the present invention may exist in granular or powder form. The granulated or powdered composition is then mixed with pharmaceutically acceptable additives and excipients to provide a final product such as a supplement product, medical device or pharmaceutical composition. The final product may be in pharmaceutical form, such as packets, tablets, pastilles or capsules.

[0027] The solid (e.g. granule or powder) composition of the invention has a bulk density (determined by means and methods known to those skilled in the art) of 0.3 to 0.8 g / ml, preferably 0.4 to 0.7 g / ml, iron(III) content 60 to 140 mg / g, preferably 80 to 120 mg / g, more preferably 90 to 110 mg / g.

[0028] Tablets may be of various shapes known in the art of pharmaceutical form...

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Abstract

The present invention relates to an iron-based composition, for use in conditions of total or relative iron deficiency. In particular, the present invention relates to a solid composition, preferablyin the form of powder or granules, for use in the treatment of disorders or diseases related to or derived from an iron deficiency. The composition of the present invention is suitable for pediatric subjects, adolescents, athletes, men, women, pregnant women and elderly. Finally, the present invention relates to a process for preparing said solid composition.

Description

[0001] This application is a divisional application, the international application number of the original application is PCT / IB2013 / 001659, the international application date is July 30, 2013, the Chinese national application number is 201380040500.1, and the entry date for entering the Chinese national phase is 2015 January On March 30, the title of the invention was "Iron-containing solid composition for iron deficiency conditions". technical field [0002] The present invention relates to an iron-based composition for use in conditions of complete or relative iron deficiency. In particular, the present invention relates to a solid composition, preferably in powder or granule form, for use in the treatment of conditions or diseases associated with or caused by iron deficiency. The compositions of the present invention are suitable for use in pediatric subjects, adolescents, athletes, males, females, pregnant women and the elderly. Finally, the invention relates to a process...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K33/42A61K9/16A23L33/16A61K47/14A61K47/24A61P3/02
CPCA61K9/1617A61K9/1623A61K9/1652A61K33/26A61K33/42A61K47/14A61K9/0095A61K47/24A61P3/02A61P7/06
Inventor A·拉考尔特G·塔伦蒂诺
Owner ALESCO SRL
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