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Ginkgo seed extract capable of relieving cough and asthma and composition, extraction method and application

An extraction method and ginkgo kernel technology are applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of large doses, large toxic and side effects of ginkgo, and potential safety hazards, and achieve low liver and kidney toxicity. Effect

Active Publication Date: 2020-06-12
GUANGXI XINHAI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the polysaccharides, proteins, oils, ginkgolic acid and other invalid or even toxic ingredients contained in ginkgo fruit are taken, resulting in excessive clinical dosage and potential safety hazards
At present, there are limitations in the development and utilization of ginkgo. The toxic and side effects of ginkgo are relatively large. How to achieve better medicinal effects and less toxicity by taking a small amount of ginkgo is the current development and research direction

Method used

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  • Ginkgo seed extract capable of relieving cough and asthma and composition, extraction method and application
  • Ginkgo seed extract capable of relieving cough and asthma and composition, extraction method and application
  • Ginkgo seed extract capable of relieving cough and asthma and composition, extraction method and application

Examples

Experimental program
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Effect test

example 1

[0028] 500 kg of dried ginkgo kernels were crushed to obtain crushed ginkgo kernels. The ratio of liquid to liquid was 1:5, and 2500L of 20vol.% ethanol solution was used to heat and reflux for 1 hour to separate the filter residue and extract, and then use 2500L of 20vol.% ethanol solution to filter residue. .% ethanol solution, heated to reflux for 1 hour, separated to obtain the filter residue and the extract, and then used 2500 L of 20vol.% ethanol solution for the filter residue, heated and refluxed for 1 hour, separated to obtain the filter residue and the extract, combined three times of the extract, filtered, and the filtrate Concentrate until there is no alcohol smell, and set the volume to 500L (1.0g crude drug / 1mL extract) to obtain the initial extract. At this time, red fruit acid, N-(1-glucosyl-indole 3-acetyl)-aspartic acid The weight ratio of N-(1-glucosyl-indole 3-acetyl)-glutamic acid is about 1:2:1 in steps a and b, adjust the pH to 3 with hydrochloric acid so...

example 2

[0030] 500 kg of dried ginkgo kernels were crushed to obtain crushed ginkgo kernels. The ratio of material to liquid was 1:6, and 3000L of 35vol.% ethanol solution was used to heat and reflux for 1 hour to separate the filter residue and extract, and then use 3000L of 35vol.% ethanol solution to obtain the filter residue. .% ethanol solution, heated to reflux for 1 hour, separated to obtain the filter residue and the extract, and then used 3000 L of 35vol.% ethanol solution for the filter residue, heated and refluxed for 1 hour, separated to obtain the filter residue and the extract, combined three times of the extract, filtered, and the filtrate Concentrate until there is no alcohol smell, and set the volume to 500L (1.0g crude drug / 1mL extract) to obtain the initial extract. At this time, red fruit acid, N-(1-glucosyl-indole 3-acetyl)-aspartic acid , The weight ratio of N-(1-glucosyl-indole 3-acetyl)-glutamic acid is step a, b is about 1:2:1, adjust the pH to 3.5 with hydroch...

example 3

[0032]500 kg of dried ginkgo kernels were crushed to obtain crushed ginkgo kernels. The ratio of material to liquid was 1:7, and 3500L of 60vol.% ethanol solution was used to heat and reflux for 1 hour to separate the filter residue and extract, and then use 3500L of 60vol. .% ethanol solution, heated and refluxed for 1 hour, separated to obtain the filter residue and the extract, combined the two extracts, filtered, concentrated the filtrate to no alcohol smell, and settled the volume to 500L (1.0g crude drug / 1mL extract) to obtain the initial Liquid extraction, at this moment, the weight ratio of red fruit acid, N-(1-glucosyl-indole 3-acetyl)-aspartic acid, N-(1-glucosyl-indole 3-acetyl)-glutamic acid For step a, b is about 1:2:1, adjust the pH to 4 with hydrochloric acid solution, centrifuge at 6000r for 5min, take the upper layer of liquid medicine, take 50 kg of NKA-2 macroporous resin (wet mass, about 75L), and use wet method Slowly load it into the column (diameter-to-h...

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Abstract

The invention discloses a ginkgo seed extract extraction method. The method comprises the following steps: a, crushing: crushing a ginkgo seed to obtain crushed ginkgo seeds; b, carrying out alcohol extraction: carrying out reflux extraction on the crushed ginkgo seeds obtained in the step a by using a 20-60vol.% ethanol solution, filtering, and concentrating a filtrate till that there is no alcohol smell so as to obtain a primary extracting solution; c, carrying out macroporous resin enrichment: adjusting a pH value of the primary extracting solution obtained in the step b to 3-4, centrifuging, taking an upper-layer liquid medicine, loading a sample, flushing a resin column with a 30-45vol.% ethanol solution, collecting an eluent, adjusting the pH value to 6-7, carrying out reduced pressure concentration, and drying to obtain a purified product; and d, drying: dissolving with alcohol, filtering, and concentrating the filtrate till that there is no alcohol smell to obtain an extract powder, namely the ginkgo seed extract. The invention also discloses the ginkgo seed extract, a composition and an application. Effective components with effects of relieving cough and asthma are possessed, contents of the main components are clear, and relatively low toxicity is achieved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine. More specifically, the present invention relates to a ginkgo kernel extract for relieving cough and relieving asthma, its composition, extraction method and application. Background technique [0002] Ginkgo is the dry mature seed of Ginkgo biloba L., a plant of Ginkgoaceae. Harvest when the seeds are mature in autumn, remove the fleshy outer testa, wash, steam or boil slightly, and dry. In traditional clinical application, ginkgo is used in combination, and there is no single application report. And in practical application, ginkgo is mostly used in decoction. Therefore, the polysaccharides, proteins, oils, ginkgolic acid and other invalid or even toxic components contained in the ginkgo are all taken, resulting in excessive clinical dosage and potential safety hazards. At present, there are limitations in the development and utilization of ginkgo fruit. The toxic and sid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P11/06A61P11/14
CPCA61K36/16A61K2236/333A61K2236/55A61P11/06A61P11/14
Inventor 杨世林
Owner GUANGXI XINHAI PHARM TECH CO LTD
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