Centrifugal mother liquor recovery treatment process for synthesizing beta-lactam antibiotics by enzymic method

A lactam, enzymatic synthesis technology, applied in the purification/separation/stabilization of antibiotics, antibiotics, organic compounds, etc., can solve the problems of adverse effects on product quality, low yield of antibiotic parent nucleus, etc., to reduce waste water generation. Quantity and salinity and organic composition, avoidance of waste, effect of broad application prospects

Pending Publication Date: 2020-06-12
山东钧睿科技服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of the chemical method are: 1-use more chemicals and chemical solvents, 2-beta-lactam antibiotics have a low yield of mother nuclei, 3-has an adverse effect on product quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This embodiment provides a process for recovering and treating centrifuged mother liquor of enzymatically synthesized β-lactam antibiotics, said process comprising the following steps:

[0027] (1) Carry out vacuum distillation to remove the residue of acetone solvent by enzymatically synthesizing the centrifuged mother liquor of β-lactam antibiotics;

[0028] (2) The mother liquor from which acetone has been removed in step (1) is first subjected to coarse filtration, then ultrafiltration, and then electrodialysis at a pH of 3-6 to obtain two parts of the solution, one of which is rich in β-lactams Antibiotic products and the core of β-lactam antibiotics; the other part contains more side chains and salts.

Embodiment 2

[0030] This embodiment provides a process for recovering and treating centrifuged mother liquor of enzymatically synthesized β-lactam antibiotics, said process comprising the following steps:

[0031] (1) Carry out vacuum distillation at normal temperature with the centrifuged mother liquor of enzymatically synthesized β-lactam antibiotics, the vacuum tightness is 0.05MPa, removes the residue of acetone solvent;

[0032] (2) step (1) is removed the mother liquor of acetone and adopts the filter screen that aperture is 20 microns to carry out coarse filtration earlier, carries out ultrafiltration again, and the ultrafiltration membrane that adopts can cut off the material that molecular weight is 5000-10000Da, and described ultrafiltration The pressure is 3 x 10 5 Pa, the temperature during the ultrafiltration is normal temperature, and the pH of the solution during the ultrafiltration is 3.5; then electrodialysis is carried out under the condition of pH 3.5 to obtain two parts...

Embodiment 3

[0034] This embodiment provides a process for recovering and treating centrifuged mother liquor of enzymatically synthesized β-lactam antibiotics, said process comprising the following steps:

[0035] (1) Carry out vacuum distillation at normal temperature with the centrifuged mother liquor of enzymatically synthesized β-lactam antibiotics, the vacuum degree is 0.06MPa, removes the residue of acetone solvent;

[0036] (2) step (1) is removed the mother liquor of acetone and adopts the filter screen that aperture is 10 microns to carry out coarse filtration earlier, carries out ultrafiltration again, and the ultrafiltration membrane that adopts can cut off the material that molecular weight is 5000-10000Da, and described ultrafiltration The pressure is 2 x 105 Pa, the temperature during the ultrafiltration is normal temperature, and the pH of the solution during the ultrafiltration is 4.5; then under the condition of pH 4.5, bipolar membrane electrodialysis is used to separate, ...

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Abstract

The invention relates to a centrifugal mother liquor recovery treatment process for synthesizing beta-lactam antibiotics by an enzymic method. The method comprises the following steps: separating beta-lactam antibiotic centrifugal mother liquor synthesized by an enzymic method by sequentially using rough filtration, ultrafiltration and electrodialysis methods to obtain a part of beta-lactam antibiotic-rich product and beta-lactam antibiotic mother nucleus, and directly applying the beta-lactam antibiotic-rich product and the beta-lactam antibiotic mother nucleus to an enzymic method synthesisprocess; and the other part contains more side chains and salts and can be hydrolyzed by an enzyme method or separated and extracted by a chemical method. The process has the beneficial effects that according to the centrifugal mother liquor recycling treatment process for synthesizing the beta-lactam antibiotics by the enzymic method, the cost for synthesizing the beta-lactam antibiotics is greatly reduced, the yield, salt and organic matter components of wastewater are remarkably reduced in the treatment process, and the centrifugal mother liquor recycling treatment process is a greener andmore environment-friendly treatment process and has a wide application prospect.

Description

technical field [0001] The invention relates to a recovery and treatment process, in particular to a recovery and treatment process for centrifuged mother liquid of beta-lactam antibiotics synthesized by enzymatic method. Background technique [0002] In the 1960s, β-lactam antibiotics began to be produced and used in related industries, which can inhibit the transpeptidation reaction catalyzed by peptide transpeptidase, so that linear polymers cannot be cross-linked into a network model, and inhibit adhesion Peptide synthesis, by preventing the formation of the cell wall, renders the cell nonviable. At present, β-lactam antibiotics and penicillin together constitute the leading products in the field of antibiotics in a wide range of fields. Enzymatic synthesis of β-lactam antibiotics has a wide range of applications, and has great advantages over chemical processes. Its cost is lower, and it is safe and environmentally friendly. The advantages are obvious, which is the dir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07B63/00C07G11/00
CPCC07B63/00C07G11/00
Inventor 陈玉波
Owner 山东钧睿科技服务有限公司
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