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Heparin-containing blood sample detection kit and preparation method thereof

A blood sample detection and kit technology, applied in the field of heparin-containing blood sample detection kits and their preparation, can solve the problems of poor dalteparin detection ability and lack of sensitivity, and achieve the effect of good sensitivity

Pending Publication Date: 2020-06-26
郑州普湾医疗技术有限公司
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, thromboelastography (TEG) sometimes lacks sufficient sensitivity when detecting heparin-containing blood samples, that is, it can detect unfractionated heparin and some low-molecular-weight heparins well, but the detection ability of dalteparin is poor

Method used

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  • Heparin-containing blood sample detection kit and preparation method thereof
  • Heparin-containing blood sample detection kit and preparation method thereof
  • Heparin-containing blood sample detection kit and preparation method thereof

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Embodiment Construction

[0028] In the following, only some exemplary embodiments are briefly described. Those skilled in the art could modify the described embodiments in various different ways, all without departing from the spirit or scope of the present invention.

[0029] Thromboelastography (TEG) detection features are described as follows:

[0030] Blood clotting time R: The time required for blood coagulation factors such as thrombin to be fully activated, the formation of fibrin clot to start, and the amplitude of the thrombelastography instrument to reach 2mm. Prolonged R value indicates the lack of certain coagulation factors; shortened R value indicates a hypercoagulable state of blood.

[0031] Clot formation time K: the time required from the end of the R value time to the amplitude of the thromboelastography instrument reaching 20 mm, reflecting the interaction between fibrin and platelets at the beginning of coagulation formation. The length of K value reflects the level of fibrinoge...

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Abstract

The invention provides a heparin-containing blood sample detection kit and a preparation method thereof. The kit comprises a reagent 1, a reagent 2, a common cup and a heparinase cup. The reagent 1 contains kaolin, sodium chloride and purified water; the reagent 2 contains calcium chloride, sodium chloride and purified water; the heparinase cup is coated with heparinase and a freeze-drying protective agent; and the common cup is an empty test cup. According to the invention, different reactivity of the diagnostic reagent to heparin-containing drug blood is fully considered, and the kit has good sensitivity to heparin drugs commonly used clinically at present, including common heparin, dalteparin, enoxaparin, nadroparin, paheparin, paheparin and the like. The heparin-containing blood sampledetection kit is used for heparin-containing blood detection, the detection result accuracy is good, and the intra-batch precision and the inter-batch precision are high.

Description

technical field [0001] The invention relates to the field of blood coagulation detection, in particular to a heparin-containing blood sample detection kit and a preparation method thereof. Background technique [0002] Thromboelastography (TEG) is a coagulation function analyzer that implements real-time, dynamic and continuous monitoring of the entire process of platelet aggregation, coagulation, fibrinolysis, etc., and makes qualitative or quantitative analysis of the patient's coagulation status. [0003] Thromboelastography was invented by German Harter in 1948. It is used to guide blood transfusion during clinical operations. It has become one of the most important means to detect blood coagulation function. The principle of thromboelastography to detect blood coagulation function is to immerse the sensor probe in the blood sample. There is a viscous force between the blood sample and the sensor probe. The viscous force changes with changes in platelet aggregation, coag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N11/10
CPCG01N11/10
Inventor 马玉坤张娟丽于婷李伟甲孟兵涛赵晓培
Owner 郑州普湾医疗技术有限公司
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