Oral, nose and throat two-component spray with antibacterial and antiviral functions and preparation method of spray

An anti-viral, two-component technology, applied in the direction of anti-viral agents, medical preparations with non-active ingredients, anti-bacterial drugs, etc., can solve the problems of mask shortage and increase the risk of infection, and achieve good biocompatibility, The effect of good antibacterial properties

Pending Publication Date: 2020-07-10
重庆九康医疗研究院有限公司
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also impossible for the human body to wear a mask all the time. When eating, drinking, and exercising, the mask will be removed when breathing rapidly, which may allow particles with bacteria or viruses to take advantage of it and increase the risk of infection
And in the early stage of the outbreak, masks will also be in short supply

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral, nose and throat two-component spray with antibacterial and antiviral functions and preparation method of spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The present embodiment provides a two-component spray for the nasal cavity, including independently packaged first and second components:

[0039] The composition of the first component: 0.5% chitosan hydrochloride, 2.2% sodium chloride, 0.05% glycerin, pH regulator, purified water.

[0040] The composition of the second component: 0.5% sodium hyaluronate, 2.2% sodium chloride, 0.05% glycerin, pH regulator, purified water.

[0041] Among them, the deacetylation degree range of the water-soluble chitosan used is 85-95%, and when the concentration is 10g / L, the viscosity range is 50-100mpa·s at 20°C, which not only has good water solubility, but also has a high viscosity Suitable, easy to spray and good film forming.

[0042] The two-component spray for the nasal cavity of the present embodiment comprises the following preparation steps:

[0043] Step 1. Under GMP purification conditions, add pure water, sodium chloride and glycerin into a clean container, control the r...

Embodiment 2

[0048] This embodiment provides a two-component spray for oral cavity including the first component and the second component of independent packaging:

[0049] The composition of the first component: 0.2% gelatin, 1% sodium chloride, 1% glycerin, pH regulator, purified water.

[0050] The composition of the second component: 0.2% sodium alginate, 1% sodium chloride, 1% glycerin, pH regulator, purified water.

[0051] The two-component spray for oral cavity of the present embodiment comprises the following preparation steps:

[0052] Step 1. Under GMP purification conditions, add pure water, sodium chloride and glycerin into a clean container, control the reaction temperature at 50-60°C, add gelatin under low-speed stirring, and continue stirring until a transparent and uniform solution is formed;

[0053] Step 2. Under GMP purification conditions, add pure water, sodium chloride and glycerin into another clean container, control the reaction temperature at 50-60°C, add sodium...

Embodiment 3

[0057] This embodiment provides a two-component spray for throat including independently packaged first component and second component:

[0058] The composition of the first component: 0.2% guar gum, 1.1% sodium chloride, 2% glycerin, pH regulator, purified water.

[0059] The composition of the second component: 0.2% sodium alginate, 1.1% sodium chloride, 2% glycerin, pH regulator, purified water.

[0060] The two-component spray for throat of the present embodiment comprises the following preparation steps:

[0061] Step 1. Under GMP purification conditions, add pure water, sodium chloride and glycerin into a clean container, control the reaction temperature at 50-60°C, add guar gum under low-speed stirring, and continue stirring until a transparent and uniform solution is formed;

[0062] Step 2. Under GMP purification conditions, add pure water, sodium chloride and glycerin into another clean container, control the reaction temperature at 50-60°C, add sodium alginate unde...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
viscosityaaaaaaaaaa
Login to view more

Abstract

The invention relates to an oral, nose and throat two-component spray with antibacterial and antiviral functions. The spray comprises a first component and a second component separately encapsulated;the first component contains a cationic biological component, glycerin, sodium chloride, purified water and a pH regulator, the cationic biological component is one or a combination of water-soluble chitosan, gelatin and guar gum, and the mass concentration of the cationic biological component in the first component is 0.1-2%; and the second component contains an anionic biological component, glycerin, sodium chloride, purified water and a pH regulator, the anionic biological component is one or a combination of an alginate, sodium hyaluronate and polyglutamic acid, and the concentration of the anionic biological component in the second component is 0.1-2%. The spray is used to prevent the infection of bacteria or viruses in the upper respiratory tracts such as nasal cavity, oral cavity and throat, and protect the health of human respiratory tracts; and the spray can be used as a ''liquid mask'' that can quickly protect human respiratory tract cells in a special period.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an oral, nose and throat two-component spray with antibacterial and antiviral functions. Background technique [0002] In recent years, with the intensification of industrial pollution, the types of particulate matter in the air have become more and more extensive. Whether it is particulate matter itself (especially PM2.5) or composite particles adsorbed with toxic and harmful substances such as bacteria and viruses, once it enters the human body through the respiratory system, it may cause potential respiratory diseases and other complications, seriously endangering human health. healthy. Especially recently, the worldwide pandemic of the novel coronavirus (SARS-CoV-2) has aroused people's attention on how to effectively protect against respiratory-related diseases. Studies have shown that the size of the droplet core containing the new coronavirus is only in the submicron to micr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/36A61K47/42A61K47/02A61K47/34A61P31/12A61P31/04A61P11/00A61P11/02A61P11/04
CPCA61K9/12A61K9/0043A61K9/006A61K9/0078A61K47/36A61K47/42A61K47/02A61K47/34A61P31/12A61P31/04A61P11/00A61P11/02A61P11/04
Inventor 景德强朱楚洪李英豪
Owner 重庆九康医疗研究院有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap