Midazolam and sodium valproate medical composition and preparation method thereof
A technology of midazolam and sodium valproate, which is applied in the field of pharmacy and pharmacy, can solve the problems of no statistically significant difference in adverse reactions of diazepam and short effective time, so as to improve safety and effectiveness, Fast and easy to use effect
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Embodiment 1
[0036] The preparation of the pharmaceutical composition 1 of midazolam and sodium valproate:
[0037] Accurately weigh 50 mg of midazolam, dissolve it in 7 mL of absolute ethanol, add 15 mL of mPEG350 to the above solution, and mix it uniformly by ultrasonication for 2 minutes, then add 18 mL of PEG400, and stir evenly to obtain solution 1; accurately weigh sodium valproate 30.0g, dissolved in 35mL purified water, add 25mL mPEG350 to the above solution, stir to mix evenly to obtain solution 2; add solution 2 dropwise to solution 1 until the solution is clear to obtain midazolam valproate drug combination Object 1.
Embodiment 2
[0039] The preparation of the pharmaceutical composition 2 of midazolam and sodium valproate:
[0040] Accurately weigh 0.5g of midazolam, dissolve it in 7mL of absolute ethanol, add 35mL of mPEG350 to the above solution, ultrasonicate for 2min to mix evenly, then add 18mL of PEG400, stir evenly to obtain solution 1; accurately weigh valproic acid Dissolve 12.5g of sodium in 21mL of purified water, add 19mL of mPEG350 to the above solution, stir to mix evenly to obtain solution 2; add solution 2 dropwise to solution 1 until the solution is clear to obtain midazolam valproate drug Composition 2.
Embodiment 3
[0042] The preparation of the pharmaceutical composition 3 of midazolam and sodium valproate:
[0043] Accurately weigh 1.0g of midazolam, dissolve it in 12mL of absolute ethanol, add 39mL of mPEG350 to the above solution, and ultrasonically mix for 2min to obtain solution 1; accurately weigh 25.0g of sodium valproate, dissolve it in 28mL Add 21 mL of mPEG350 to the above solution in purified water, stir to mix evenly to obtain solution 2; add solution 2 dropwise to solution 1 until the solution is clear to obtain midazolam sodium valproate pharmaceutical composition 3.
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