Drug delivery systems and methods

A catheter, main body technology, applied in the field of drug delivery systems and methods, can solve the problems of harmful, difficult to distribute, inefficient patients, etc.

Pending Publication Date: 2020-07-17
ALCYONE LIFESCIENCES INC
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, achieving desired or ideal drug distribution via intrathecal delivery can be difficult due at least in part to the natural CSF flow in the patient's body that tends to oscillate and pulse with little net flow
Traditional techniques involving the delivery of large quantities of drug into the intrathecal space and relying on natural diffusion to distribute the drug are inefficient and potentially harmful to the patient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drug delivery systems and methods
  • Drug delivery systems and methods
  • Drug delivery systems and methods

Examples

Experimental program
Comparison scheme
Effect test

example A

[0194] Alternate pulsatile infusions of drug (pump 1) and buffer / saline (pump 2)

[0195] Total drug volume: 2.2mL

[0196] Total buffer volume: 4.4mL

[0197] Infusion rate with two pumps: 15mL / min

[0198] Circulation: 10 cycles in the lumbar area then 10 cycles in the cisterna magna

[0199] Time between loops: 100ms

[0200] Infusion Description: In the lumbar region, pump 1 infused 0.11 mL at 15 mL / min with a 100-ms pause, and pump 2 infused 0.22 mL at 15 mL / min with a 100-ms pause (cycle 1). This is repeated at the waist for a total of 10 cycles. The catheter is threaded upwards into the cisterna magna. Pump 1 infused 0.11 mL at 15 mL / min with a 100-ms pause, and pump 2 infused 0.22 mL at 15 mL / min with a 100-ms pause (cycle 1). This was repeated for a total of 10 cycles in the cisterna magna.

example B

[0202] Alternate pulsatile infusions of drug (pump 1) and buffer / saline (pump 2)

[0203] Total drug volume: 3mL

[0204] Total buffer volume: 20mL

[0205] Infusion rate of two pumps: 4mL / min

[0206] Cycles: 13 cycles in the chest area

[0207] Time between alternating pump 1 to pump 2: 1000 ms

[0208] Time between cycles (pump 2 to pump 1): 5000 milliseconds

[0209] Infusion Description: In the lumbar region, pump 1 infused 0.231 mL at 4 mL / min with a 1000 ms pause, pump 2 infused 2.0 mL at 4 mL / min with a 5000 ms pause (cycle 1). This is repeated for a total of 13 cycles in the chest area.

example C

[0211] Alternate pulsatile infusions of drug (pump 1) and buffer / saline (pump 2)

[0212] Total drug volume: 5mL

[0213] Total buffer volume: 8mL

[0214] Infusion rate of pump 1: 37 mL / min

[0215] Infusion rate of pump 2: 20 mL / min

[0216] Cycles: 5 cycles in the chest area

[0217]Time between loops: 10ms

[0218] Infusion Description: In the lumbar region, pump 1 infused 1 mL at 37 mL / min with a 10-ms pause, and pump 2 infused 1.6 mL at 30 mL / min with a 100-ms pause (cycle 1). This is repeated for a total of 5 cycles on the chest area.

[0219] Figure 22 Drug delivery system 200 including lumbar puncture needle 292 is illustrated. Needle 292 may include a sensor 294 (eg, a pressure sensor) mounted adjacent the distal tip of the needle. Thus, as needle 292 is inserted into patient 210, sensor 294 may measure pressure or other characteristics of the patient's CSF. Needle 292 may also include an integrated or remote display 296 for displaying the output of sensor ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of usingsuch systems.

Description

[0001] This application has priority to U.S. Provisional Patent Application No. 62 / 437,168, filed December 21, 2016, which is incorporated herein by reference in its entirety. technical field [0002] Disclosed herein are systems and methods for delivering drugs to a subject (eg, via intrathecal delivery to the cerebrospinal fluid (CSF) or subarachnoid space of the subject's brain or spine). Background technique [0003] In many situations, it may be desirable to deliver a drug to a patient. As used herein, the term "drug" refers to any functional agent that can be delivered to a human or animal subject, including hormones, stem cells, gene therapy, chemicals, compounds, small and large molecules, dyes, antibodies, viruses, therapeutic agent etc. [0004] Delivery of the drug can be accomplished systemically, or can be targeted to a specific location or pattern of distribution. However, targeted drug delivery can be challenging because there are many situations where the d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61B17/34A61M5/14A61M5/142A61M5/145A61M5/158A61M25/14
CPCC12N15/111A61M5/14546C12N2310/11C12N2320/32A61M2210/1003A61M2210/0693A61M2230/06A61M2230/42A61M2205/3303A61M2205/3331A61M2205/52A61M2005/1726A61M5/007C12N15/113A61M2205/3584A61M2205/502A61M5/1408A61M2025/0024A61M5/172A61M5/19A61M5/1723C12N2320/35A61M5/168A61M25/0017A61M25/003A61M25/0032A61M25/0045A61M25/0147A61M25/09A61M25/1002A61M25/1011A61M39/0208A61M2025/0007A61M2025/1052A61M2205/0266
Inventor P·阿南德M·布罗菲德普阿琼·辛格G·埃贝尔A·阿祖曼德S·穆拉A·伊斯特J·弗罗因德
Owner ALCYONE LIFESCIENCES INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap