Zirconium-based cluster as an antiperspirant and deodorant active
A technology of zirconium clusters and zirconium oxychloride clusters, which can be used in deodorization, zirconium compounds, descaling and water softening, etc. It can solve the problems that low pH value cannot be used, zirconium compounds reduce the efficacy of antiperspirant, etc.
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example 1
[0081] Example 1: Preparation of zirconium oxychloride clusters
[0082] Samples were prepared according to Table 1. In a glass bottle, to zirconium oxychloride (ZrOCl 2 8H 2 O, MW322.25) was added with water to obtain a clear solution containing 1% zirconium oxychloride. With stirring, add L-arginine slowly to prevent arginine aggregation and large fluctuations in local pH. The molar ratios of arginine to zirconium oxychloride were 0.5:1, 1:1, 2:1, 3:1 and 4:1, as shown in Table 1. The solution was incubated at 50°C for 1 day. Next, the solution was allowed to cool to room temperature. A solid gel was formed in the sample in which the molar ratio of arginine to zirconium oxychloride was 2-4. However, the samples were stable in terms of gelation and flocculation at pH 1.39, 1.73 and 2.59 at molar ratios of arginine to zirconium oxychloride of 0, 0.5 and 1, respectively.
[0083] Table 1.1% zirconium oxychloride with different arginines
[0084]
[0085] The samples...
example 2
[0086] Example 2: Purification of zirconium oxychloride clusters
[0087] A 100 g batch was prepared according to Table 2. Mix 1% w / w zirconium oxychloride (ZrOCl 2 8H 2 O, MW322.25) and arginine, wherein the molar ratio of arginine to zirconium oxychloride is 1:1.
[0088] Table 2. 1% zirconium oxychloride and arginine (1:1 ratio) (100 g batch)
[0089]
[0090] Zirconium oxychloride clusters were prepared as described in Example 1. The prepared zirconium oxychloride clusters were purified by gel permeation chromatography (GPC). GPC columns were prepared using Bio-Rad P2 gels with a particle size of 5 μm. Approximately 10 mL of the prepared solution was filtered (0.45 μm) and loaded onto the column at 0.2 mL / min using the HPLC pump. The mobile phase of GPC chromatography is deionized water. Fractions were collected at intervals and monitored using SEC-RI. The first material eluted exhibited an SEC peak at 6.75 minutes representing zirconium oxychloride clusters. ...
example 3
[0091] Example 3: Flocculation
[0092] One mechanism by which antiperspirants work is that the antiperspirant combines with the proteins in the sweat to form deposits that block the sweat glands. In order to test whether zirconium oxychloride clusters (also referred to herein as Zr peak 1) can precipitate in a sweat environment and thus act as an antiperspirant, bovine serum albumin (BSA) was used as a model protein to simulate the interaction between the skin surface and the sweat environment. protein found. Zirconium oxychloride clusters were prepared as described in Example 1. Specifically, in a glass bottle, 94.6 g of water was added to 3.5377 g of zirconium oxychloride (ZrOCl 2 8H 2 O), a clear solution was obtained. With stirring, 1.9104 g of L-arginine was added slowly to prevent arginine aggregation and large fluctuations in local pH. This clear solution was heated at 50°C for 24 hours. Next, the solution was allowed to cool to room temperature. After preparin...
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