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Oral care compositions and methods of using the compositions

A technology for oral care and composition, which is applied in the field of oral care composition, and can solve problems such as unpleasant astringent taste, lower utilization rate of zinc and fluoride, etc.

Active Publication Date: 2018-06-08
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zinc ions in solution impart an unpleasant astringent mouthfeel, thus formulations that provide effective levels of zinc and also have acceptable organoleptic properties are difficult to achieve
In addition, free zinc ions can react with fluoride ions to form zinc fluoride, which is insoluble, thus reducing the availability of zinc and fluoride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 - Dentifrice Formulation

[0049] A test dentifrice comprising 1% zinc phosphate in combination with 0.6% acetyl isoeugenol was prepared according to the following formula (the amounts of ingredients are listed by weight of the composition):

[0050] Table 1

[0051] Element

Embodiment 2

[0053] The efficacy of a toothpaste with both zinc phosphate and acetylisoeugenol ("the toothpaste of Example 2") was evaluated against Comparative Examples A and B and the results are shown in Table 2 below. The toothpaste of Example 2 was prepared by combining acetylisoeugenol with a commercially available zinc phosphate-containing toothpaste. Comparative Example A is the same commercial toothpaste but without acetylisoeugenol. Comparative Example B is a commercially available toothpaste containing fluoride and triclosan active agents. The procedure for assessing efficacy was as follows:

[0054]1. Plaque was collected from 4 healthy volunteers and pooled together as an inoculum. The optical density ("O.D.") of the inoculum was matched to the absorbance of 03 at 610 nm.

[0055] 2. Place sterile vertical hydroxyapatite ("HAP") discs on ACTA lids in a 24-well microplate with 1 ml sterile artificial saliva (containing 0.01% sucrose) and 1 ml confluent saliva under anaerobic...

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Abstract

An oral care composition comprises zinc phosphate and at least one anti-microbial agent chosen from engenol, isoeugenol, eugenol acetate and isoeugenol acetate. The zinc phosphate is added to the oralcare composition as a preformed salt.

Description

Background technique [0001] Dental erosion involves demineralization and damage to tooth structure due to acid erosion of non-bacterial origin. Erosion is initially found in the enamel and, if left unchecked, can progress to the underlying dentin. Acidic foods and drinks, exposure to chlorinated swimming pool water, and acid reflux can cause or exacerbate tooth erosion. Enamel is a negatively charged surface that naturally tends to attract positively charged ions such as hydrogen and calcium ions, while repelling negatively charged ions such as fluoride ions. Depending on the relative pH of the surrounding saliva, the enamel will lose or gain positively charged ions, such as calcium ions. Typically saliva has a pH between 7.2 and 7.4. As the pH decreases, the fluid medium surrounding the tooth becomes unsaturated with respect to the tooth mineral phase and the tooth dissolves, releasing calcium and phosphate ions. This damages the enamel and creates a porous, spongy rough ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/27A61K8/34A61Q11/00
CPCA61K8/347A61Q11/00A61K8/27A61K8/21A61K8/24A61K8/25A61K8/34A61K8/44A61K8/37A61K2800/28
Inventor 阿尔蒂·赖格理查德·萨利文
Owner COLGATE PALMOLIVE CO