Pharmaceutical composition for improving curative effect of paclitaxel rhythm chemotherapy in treatment of gastric cancer metastasis and preparation method and application thereof

A composition, the technology of paclitaxel, applied in the field of anti-tumor metastasis pharmaceutical composition, can solve the problems of serious adverse reactions and unsatisfactory curative effect, and achieve the effects of increasing the weight of mice, good synergistic effect, and scientific and reasonable proportioning

Active Publication Date: 2020-08-11
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, in order to obtain a higher remission rate, chemotherapeutic drugs are often used to the maximum tolerated dose (Maximun Tolerated Dose, MTD) of the body to kill the tumor to the greatest extent, but after curing the tumor or significantly prolonging the treatment of patients (especially those with advanced or existing patients with metastases) in terms of survival time, the curative effect is not ideal
At present, MTD is the main method of paclitaxel in the clinical treatment of gastric cancer, but it is usually accompanied by serious adverse reactions

Method used

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  • Pharmaceutical composition for improving curative effect of paclitaxel rhythm chemotherapy in treatment of gastric cancer metastasis and preparation method and application thereof
  • Pharmaceutical composition for improving curative effect of paclitaxel rhythm chemotherapy in treatment of gastric cancer metastasis and preparation method and application thereof
  • Pharmaceutical composition for improving curative effect of paclitaxel rhythm chemotherapy in treatment of gastric cancer metastasis and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. A pharmaceutical composition for improving the efficacy of paclitaxel rhythm chemotherapy in the treatment of gastric cancer metastasis, which includes paclitaxel and a traditional Chinese medicine composition; the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 60 g of raw Radix Astragali, 30 g of fried Radix Codonopsis, and 30 g of fried Atractylodes macrocephala. 10g, angelica 10g, white peony root 10g, trigonum 30g, curcuma 30g, woody 10g, tangerine peel 10g, roasted licorice 5g.

[0020] 2. The extraction method of the Chinese medicine composition is:

[0021] Take 60g of raw astragalus, 30g of fried Codonopsis pilosula, 10g of fried Atractylodes macrocephala, 10g of angelica, 10g of white peony, 30g of three-edged rhizome, 30g of curcuma, 10g of woody fragrance, 10g of tangerine peel and 5g of roasted licorice, soaked in 2050ml of double distilled water for 30 minutes , boil over high heat until boiling, s...

Embodiment 2

[0023] 1. A pharmaceutical composition for improving the curative effect of paclitaxel rhythm chemotherapy in the treatment of gastric cancer metastasis, which includes paclitaxel and a traditional Chinese medicine composition; the traditional Chinese medicine composition is composed of the following raw materials in parts by weight: 120g of raw Radix Astragali, 60g of fried Codonopsis pilosula, and 60g of fried Atractylodes macrocephala. 20g, angelica 20g, white peony root 20g, trigonum 60g, curcuma 60g, woody 20g, tangerine peel 20g, roasted licorice 10g.

[0024] 2. The extraction method of the Chinese medicine composition is:

[0025] Take raw astragalus 120g, stir-fry Codonopsis 60g, stir-fry Atractylodes macrocephala 20g, angelica 20g, white peony root 20g, trigonum 60g, curcuma 60g, woody fragrance 20g, tangerine peel 20g, roasted licorice 10g, soak in 4010ml double distilled water for 30 minutes , boil over high heat until boiling, simmer for 30 minutes on low heat and...

Embodiment 3

[0026] Embodiment 3 pharmacological experiment

[0027] 1. Construction and administration of gastric cancer lung metastasis model

[0028] Gastric cancer MFC cells were injected into the tail vein of 615 mice (3×10 7 cells / mL, 0.2mL / mouse) to construct gastric cancer lung metastasis model mice. After successful modeling, the mice were randomly divided into the following groups (10 mice in each group): conventional dose of paclitaxel chemotherapy group (PTX, 30 mg / kg, intraperitoneal injection, once / 5 days), paclitaxel rhythm chemotherapy group ( MC-PTX, 5mg / kg, intraperitoneal injection, qd), embodiment 1 Chinese medicine composition group (JPYZ, 34.2g / kg, gavage, qd), embodiment 1 Chinese medicine composition group combined paclitaxel metronomic chemotherapy group (MC- PTX+JPYZ, intraperitoneal injection+oral, qd), continuous administration for 14 days.

[0029] 2. The new regimen of traditional Chinese medicine composition and paclitaxel rhythm chemotherapy increases the...

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Abstract

The invention discloses a pharmaceutical composition for improving the curative effect of paclitaxel rhythm chemotherapy in treatment of gastric cancer metastasis and a preparation method and an application thereof. The pharmaceutical composition comprises paclitaxel and a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition is prepared from 60-120 parts of raw radix astragali, 30-60 parts of fried radix codonopsis, 10-20 parts of fried rhizoma atractylodis macrocephalae, 10-20 parts of radix angelicae sinensis, 10-20 parts of radix paeoniae alba, 30-60 parts of rhizoma sparganii, 30-60 parts of rhizoma curcumae, 10-20 parts of radix aucklandiae, 10-20 parts of pericarpium citri reticulatae and 5-10 parts of radix glycyrrhizae preparata. Accordingto the theory of traditional Chinese medicine, the traditional Chinese medicine composition is screened by adopting the theory of syndrome differentiation and treatment, and after the traditional Chinese medicine composition and paclitaxel are dosed according to a certain dosage, the curative effect of paclitaxel in treatment of gastric cancer pulmonary metastasis can be remarkably improved. Bonemarrow suppression caused by paclitaxel and immune function damage caused by paclitaxel can be remarkably relieved; and unexpected technical effects of very good synergistic effect, reduction of adverse effects of paclitaxel and the like are achieved.

Description

technical field [0001] The invention relates to a pharmaceutical composition for anti-tumor metastasis, in particular to a pharmaceutical composition for improving the curative effect of paclitaxel rhythm chemotherapy in treating gastric cancer metastasis, its preparation method and application. Background technique [0002] Gastric cancer is one of the most common malignant tumors in the world. According to the latest global cancer annual report, there were more than 1 million new cases of gastric cancer in 2018. According to the survey, the main cause of death in patients with gastric cancer is the recurrence and distant metastasis of gastric cancer. 50% of patients who underwent surgical resection had recurrence and metastasis within 1 year, and recurrence and metastasis within 2 years accounted for more than 70%. Local or distant metastases were found after all. Studies have shown that the therapeutic effect of only targeting the primary tumor of gastric cancer is not g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K31/337A61P35/00A61P35/04A61P37/04
CPCA61K36/481A61K36/344A61K36/284A61K36/232A61K36/71A61K36/65A61K36/902A61K36/9066A61K36/285A61K36/752A61K36/484A61K31/337A61P35/00A61P35/04A61P37/04A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 孙庆敏刘沈林吴坚邹玺陈亚玲沈照峰朱瑾
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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