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Stratified squamous epithelial cell normal differentiation and maturation promoting agent, epithelial disease therapeutic agent, and stratified squamous epithelial cell normal differentiation and maturation promoting method

A flat epithelium, disease treatment technology, applied in skin diseases, sensory diseases, pharmaceutical formulations, etc., to achieve the effect of improving tight junctions

Pending Publication Date: 2020-08-21
OSAKA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] As a conventional treatment method for dry eye syndrome, eye drops using artificial tears, the method of moisturizing assistance (Moisture Aid) that prevents tears from evaporating by assembling panels on both sides of glasses, and the method of using eye drops as tear outlets are known. The lacrimal puncta sealing method to keep the tear fluid in the conjunctival sac, the method of water retention by eye drops of hyaluronic acid, the method of promoting the secretion of mucin and water by drugs, etc., but none of these methods are satisfactory. status

Method used

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  • Stratified squamous epithelial cell normal differentiation and maturation promoting agent, epithelial disease therapeutic agent, and stratified squamous epithelial cell normal differentiation and maturation promoting method
  • Stratified squamous epithelial cell normal differentiation and maturation promoting agent, epithelial disease therapeutic agent, and stratified squamous epithelial cell normal differentiation and maturation promoting method
  • Stratified squamous epithelial cell normal differentiation and maturation promoting agent, epithelial disease therapeutic agent, and stratified squamous epithelial cell normal differentiation and maturation promoting method

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preparation example Construction

[0059] (Method for preparing mesenchymal stem cells)

[0060] Mesenchymal stem cells can be prepared by methods known to those skilled in the art. As described above, primary cells isolated from donor tissues may be used, or strained cells may be used. Hereinafter, as an example, a method for producing adipose-derived mesenchymal stem cells from primary cells will be described. For example, adipose-derived mesenchymal stem cells can be obtained by the production method described in U.S. Patent No. 6,777,231, for example, can be prepared by a method including the following steps (i) to (iii):

[0061] (i): a process of obtaining a cell suspension by digesting adipose tissue with an enzyme;

[0062] (ii): the process of sedimenting the cells and resuspending the cells in a suitable medium; and

[0063] (iii) A step of culturing cells on a solid surface and removing cells that do not show binding to the solid surface.

[0064] The adipose tissue used in step (i) is preferably...

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Abstract

The present invention addresses the problem of providing a new therapeutic agent that is effective against diseases involving stratified squamous epithelial cells such as dry eye syndrome. The presentinvention is a stratified squamous epithelial cell normal differentiation and maturation promoting agent that comprises secretions of mesenchymal stem cells. It is preferable that the secretions notinclude animal serum, that the mesenchymal stem cells be adipose-derived mesenchymal stem cells, umbilical cord-derived mesenchymal stem cells, or bone marrow-derived mesenchymal stem cells, and thatthe stratified squamous epithelial cells be at least one selected from the group consisting of corneal epithelial cells, conjunctival epithelial cells, epidermal keratinocytes, oral epithelial cells,epiglottic epithelial cells, esophageal epithelial cells, vaginal epithelial cells, vocal fold epithelial cells, nasal epithelial cells, and nasal vestibular epithelial cells.

Description

technical field [0001] The present invention relates to an agent for promoting normal differentiation and maturation of stratified squamous epithelial cells, a therapeutic agent for epithelial diseases, and a method for promoting normal differentiation and maturation of stratified squamous epithelial cells. Background technique [0002] To protect the eye from external sources of infection, the surface of the eye plays an important role. Dry eye, which is a major disease on the above-mentioned eye surface, is a chronic disease of tears, corneal epithelium, and conjunctival epithelium, and is caused by abnormalities in the quality or quantity of tears, resulting in eye discomfort and abnormal visual function. In such dry eye, severe dry eye such as Sjögren's syndrome may bring about a significant decrease in quality of life (QOL) and even blindness. In addition, the number of Sjogren's syndrome patients in Japan is 70,000, but if potential patients are included, it is said t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61P1/02A61P17/00A61P27/02A61P43/00
CPCA61K35/28A61P1/02A61P17/00A61P27/02
Inventor 西田幸二林龙平柴田峻大久保彻本间阳一
Owner OSAKA UNIV
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