8 results about "Ceramide 3" patented technology

The invention provides ginseng fermentation-dendrobium base cream with protection and nourishing functions and a preparation method and application of the ginseng fermentation-dendrobium base cream, and belongs to the technical field of cosmetics. The sun screen is mainly prepared from water-phase components such as ginseng fermentation liquor, dendrobium officinale extract, purslane flower water and tremella polysaccharide. Oil phase components such as pteroceltis tatarinowii seed oil, baobab oil and macadamia nut seed oil; sericite, titanium dioxide, zinc oxide and other powder components; the composition is prepared by compounding the raw materials, ceramide 3, ethylhexylglycerin, natural plant essential oil and other components according to a specific mass percentage and a preparation process, and the pH value is adjusted to 5.5-6.5. The sun screen has excellent physical isolation and ultraviolet ray blocking functions, deeply nourishes and repairs skin barrier, improves skin quality, and is mild and comfortable in skin feeling and remarkable in effect.

The invention belongs to the technical field of skin care products, and provides an anti-skin-aging bovine-derived protein peptide composition and a preparation method thereof. The preparation method comprises the following steps: preparing bovine-derived protein peptide with the molecular weight of 300-800Da by adopting a sequential enzymolysis technology, directionally enriching active peptide fragments with arginine and lysine content of more than or equal to 18% through cation exchange chromatography, constructing an antioxidant synergistic network with ascorbyl sodium phosphate, tocopheryl acetate and phytic acid, preparing a bionic liposome carrier by utilizing phosphatidylcholine, cholesterol and ceramide 3, and preparing the bovine-derived protein peptide biomimetic liposome. The surface of a carrier is sequentially coated with a poly L-histidine layer, a hyaluronic acid layer and a polycaprolactone outer layer by adopting a multi-layer response coating design, and is grafted with hyaluronic acid oligosaccharide to form a stable multi-layer structure. The average particle size of the prepared composition is 120-280 nm, the drug loading efficiency is larger than or equal to 82%, the 24-hour cumulative release rate is 58-82%, and the composition shows excellent controlled release performance and anti-aging activity and is suitable for development and application of high-end anti-aging skin care products.

This invention belongs to the field of skincare technology and provides an anti-aging bovine protein peptide composition and its preparation method. Bovine protein peptides with a molecular weight of 300-800 Da are prepared using sequential enzymatic hydrolysis. Active peptides with arginine and lysine content ≥18% are directionally enriched by cation exchange chromatography. These peptides are then combined with sodium ascorbate phosphate, tocopheryl acetate, and phytic acid to construct an antioxidant synergistic network. A biomimetic liposome carrier is prepared using phosphatidylcholine, cholesterol, and ceramide 3. A multilayer responsive coating design is employed, sequentially coating the carrier surface with a poly-L-histidine layer, a hyaluronic acid layer, and a polycaprolactone outer layer, and grafting hyaluronic acid oligosaccharides to form a stable multilayer structure. The prepared composition has an average particle size of 120-280 nm, a drug loading efficiency ≥82%, and a 24-hour cumulative release rate of 58-82%, exhibiting excellent controlled-release performance and anti-aging activity, making it suitable for the development and application of high-end anti-aging skincare products.

The invention provides a coated liposome as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. Comprising the following steps: (1) mixing ceramide 3, dimer dilinoleate and cholesterol, heating for melting, cooling, adding ergothioneine, and stirring and mixing to obtain an oil phase; (2) heating, stirring and mixing polyquaternium-51, bis (lauramide glutamine) sodium lysine, sodium hyaluronate, glycerol and water to obtain a water phase; (3) under a heating condition, adding the oil phase into the water phase in a trickle form, and performing ultrahigh-pressure microjet homogenization; and (4) the temperature is controlled, the speed is reduced, the temperature is reduced, the bis-PEG-18 methyl ether dimethylsilane and the pre-dispersed sodium polyacryloyldimethyl taurate are added, the materials are stirred and mixed, the coated liposome is obtained, the coated liposome is not turbid after being added into an aqueous solution, the coated liposome has good high and low temperature resistance stability, and the effects of improving skin targeted delivery and repairing skin barriers are achieved.

The invention discloses a whitening and freckle-removing fucoidan-plant extract synergistic composition as well as a preparation method and application thereof, belongs to the technical field of skin care products, and particularly relates to the whitening and freckle-removing fucoidan-plant extract synergistic composition. Comprising the following components in parts by weight: 0.3-0.5 part of fucoidan, 1.5-2.5 parts of a bighead atractylodes rhizome extract, 6-10 parts of a lactobacillus helveticus fermentation supernatant, 3-5 parts of nut oil ceramide, 8-10 parts of deep sea water minerals and 1-2 parts of arbutin. According to the invention, active functional components are compounded, complementarity on action targets and physicochemical properties is utilized, an anti-oxidation and anti-inflammatory synergistic effect is exerted, melanin generation is inhibited from the source, skin inflammatory response is relieved, and a synergistic composition which can efficiently whiten and remove freckles and also can give consideration to skin barrier health is constructed.

The application discloses an OCTN1-mitochondria double-targeting cascade delivery liposome of ergothioneine, a preparation method and application thereof, and belongs to the technical field of functional cosmetics and targeted drug preparations. The application adopts an ethanol injection method combined with a pH gradient active drug loading technology to prepare a core drug loading liposome, and sequentially modifies ceramide 3, an OCTN1 targeting ligand and a mitochondria targeting ligand on the surface, so as to construct a three-step cascade delivery system of efficient transdermal active cell uptake and mitochondria precise enrichment. The prepared liposome has an encapsulation efficiency of no less than 88%, a drug loading amount of no less than 9.8%, a 24h in-vitro transdermal cumulative permeation amount of no less than 15 mu g / cm 2 , an intracellular mitochondria enrichment rate of no less than 65%, and a mitochondria ROS clearance efficiency of no less than 87%, and the antioxidant and anti-photoaging effects of ergothioneine are significantly improved, so that the application can be widely applied to the fields of high-end anti-aging cosmetics, medical repair products and functional skin care products.

The invention relates to the technical field of external pharmaceutical preparations, and discloses a pain-treating garden balsam stem oil, which is prepared from the following raw materials: peppermint oil, natural borneol, fatty acid, propylene glycol dicaprylate / caprate, ginger oil, blumea oil, lavender oil, rose oil, olive fruit oil, simmondsia chinensis seed oil, ceramide 3, bisabolol and the like. Wherein menthol in the peppermint oil, natural borneol and fatty acid are assembled through hydrogen bonds to form a ternary eutectic solvent system, and propylene glycol dicaprylate / caprate is used as a low-temperature stabilizer. By constructing a ternary eutectic solvent system, the problem that high-concentration borneol is easy to crystallize at low temperature is solved, and the antioxidant stability of gingerol is remarkably improved by utilizing a hydrogen bond clamping process. Meanwhile, by adding ceramide 3 and bisabolol, the synergism of a powerful transdermal effect and skin barrier repair is realized, the irritation of the preparation is reduced to a non-irritation level, and the drug effect, stability and safety are effectively improved.

The invention belongs to the field of new daily chemical materials, and discloses a bionic tire fat composition which comprises the following components in parts by weight: 6-10 parts of squalane; 7 to 13 parts of phytosterols; 10 to 17 parts of borage seed oil; 10 to 20 parts of rice germ oil; 2 to 6 parts of lecithin; 2 to 5 parts of ceramide 3; 3 to 7 parts of lactoferrin; 3 to 7 parts of whey protein; 15 to 25 parts of hydrolyzed keratin; 8-12 parts of amino acid; the water is added until the total amount of the composition is 100 parts. The composition achieves the effects of resisting inflammation, preserving moisture, resisting irritation, repairing skin barriers and the like by compounding lipid and protein related components, namely bionic fetal fat components and verifying the effects through skin care cream; meanwhile, the invention further discloses a preparation method and application of the composition.