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The application of the extract of Azalea vine in the preparation of antineoplastic drugs

An anti-tumor drug, the technology of red vine, applied in the field of anti-tumor medicine, can solve the problems of drug resistance of tumor cells, complex tumor pathology, etc., and achieve the effects of low toxicity, strong drug efficacy, and reduced leaching.

Active Publication Date: 2022-03-25
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although many single or compound medicinal materials or their extracts have been found to have anti-tumor effects in recent decades, due to the many types of tumor cells, the complex pathology of tumors, and the limitations of the efficacy of existing anti-tumor drugs, drugs Long-term use will cause side effects or tumor cell drug resistance; therefore, continuous research and development of new drugs, breaking the limitations of drug efficacy, reducing drug side effects and drug resistance of tumor cells are still the key to the treatment and prevention of tumors

Method used

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  • The application of the extract of Azalea vine in the preparation of antineoplastic drugs
  • The application of the extract of Azalea vine in the preparation of antineoplastic drugs
  • The application of the extract of Azalea vine in the preparation of antineoplastic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The extraction method of the ethanolic extract of the red vine includes the following steps:

[0026] (1) Put the decoction pieces of the vines in a dipping container, add 70% ethanol to cover the decoction pieces of the vines, and immerse the pieces continuously for 4 times. The immersion time is 7 days, 5 days, 5 days, and 5 days. Filtration was performed after each immersion, the filtrate was separated, and the filtrate was combined.

[0027] (2) Concentrate the combined filtrate obtained above on a rotary evaporator at 55°C and recover ethanol to obtain a concentrated solution and place it on a water bath at 55°C and further concentrate it to extract, to obtain the ethanolic extract of Candida vulgaris.

Embodiment 2

[0029] The extraction method of the ethanolic extract of the red vine includes the following steps:

[0030] (1) Take the decoction pieces of the vines and place them in the dipping container, add ethanol with a volume concentration of 20% to cover the decoction pieces of the vines, and immerse the pieces continuously for 5 times. The immersion time is 6 days, 4 days, 4 days, 4 days, After 4 days, filtration was performed after each immersion, the filtrate was separated, and the filtrate was combined.

[0031] (2) Concentrate the combined filtrate obtained above on a rotary evaporator at 50 °C and recover ethanol, and place the concentrated solution in a water bath at 50 °C to further concentrate to extract, to obtain the ethanolic extract of Candida chinensis.

Embodiment 3

[0033] The extraction method of the ethanolic extract of the red vine includes the following steps:

[0034] (1) Take the decoction pieces of the vines and place them in the dipping container, add ethanol with a volume concentration of 100% to cover the decoction pieces of the vines, and immerse the pieces continuously for 3 times. The immersion time is 8 days, 6 days, and 6 days. Filtration was performed after completion|finish, the filtrate was separated, and the filtrate was combined.

[0035] (2) Concentrate the combined filtrate obtained above on a rotary evaporator at 60 °C and recover ethanol, and place the concentrated solution on a water bath at 60 °C to further concentrate to extract, to obtain the ethanolic extract of Candida chinensis.

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Abstract

The present invention discloses an application of the extract of A. versicolor in the preparation of antineoplastic drugs. The application is to apply the ethanol extract of A. fructus and its preparation to the preparation of drugs for treating lung cancer, cervical cancer, liver cancer and / or gastric cancer . The present invention firstly applies the extract of Azalea to the technical field of preparation of antitumor drugs, and provides a new way and means for treating and curing tumors.

Description

technical field [0001] The invention relates to the technical field of anti-tumor medicines, in particular to the application of an extract of Acanthus chinensis in the preparation of anti-tumor medicines. Background technique [0002] Red vine (scientific name: Erythropalum scandens Bl. ) is the family of Astragalus ( Olacaceae ) Acanthus ( Erythropalum ) perennial evergreen large woody vine. Red Cang vine has high edible, medicinal and landscaping ornamental value, and is mainly produced in Yunnan, Guizhou, Guangxi, Guangdong and other places. The root of the red vine contains phenolic components, resins and triterpenes, and the main components of the resins are sumaric acid and coniferyl cinnamonate. Chi Cang Teng is bitter in taste, flat in nature, enters the liver and kidney meridians, and has the effect of clearing away heat and diuresis. [0003] So far, there are not many researches on the vines, and the applicant has analyzed the chemical constituents of the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61P35/00
CPCA61K36/185A61P35/00A61K2236/333A61K2236/51
Inventor 梁臣艳唐云丽吴捷梅潘翠柳何柳艳张璐
Owner GUANGXI UNIV OF CHINESE MEDICINE