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A layer-by-layer self-assembled chitin whisker-modified polylactic acid composite material and its preparation method and application

A technology of chitin whiskers and layer-by-layer self-assembly, which is applied in coatings, tissue regeneration, prostheses, etc., can solve problems such as weak force, difficulty in ensuring stable attachment of whisker layers, and difficulty in meeting individual requirements. The preparation process is simple and practical, the mechanical properties are controllable, and the effect of good application prospects

Active Publication Date: 2022-08-05
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, simply coating the chitin whisker suspension on the surface of the polylactic acid film by the flow coating process can neither control the thickness of the chitin whisker layer nor ensure the uniformity of the thickness of the chitin whisker layer. The change in performance is directly related to the thickness of the chitin whisker layer. The thickness of the chitin whisker layer cannot be controlled by the flow coating process, so the mechanical properties of the composite film cannot be flexibly adjusted, so it is difficult to meet the individuality of different bone tissue repairs on the mechanical properties of the material. requirements
In addition, the simple accumulation of chitin whiskers with the same charging properties will lead to a weak force between whiskers in the chitin whisker layer, and it is difficult to ensure that the whisker layer is stably attached to the film surface. It will reduce the stability and biological function of the composite membrane during application

Method used

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  • A layer-by-layer self-assembled chitin whisker-modified polylactic acid composite material and its preparation method and application
  • A layer-by-layer self-assembled chitin whisker-modified polylactic acid composite material and its preparation method and application
  • A layer-by-layer self-assembled chitin whisker-modified polylactic acid composite material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1: Preparation of self-assembled chitin whisker-modified polylactic acid composites

[0047] Step 1: Weigh 1.0 part by mass of racemic polylactic acid (PDLLA) particles with a weight-average molecular weight of 15w, and pour it into 15 parts by volume of chloroform to dissolve. After stirring and dissolving for 8 h, the solution was subjected to ultrasonic treatment for 5 min to remove air bubbles in the solution, and then poured into a PTFE petri dish for molding. After volatilizing at room temperature for 12 h, it was put into a vacuum drying oven at 40° C. for vacuum drying for 6 h to completely remove the organic solvent, and a PDLLA film was obtained. The PDLLA membrane was further immersed in a 1.0 g / L dopamine hydrochloride Tris buffer solution (pH=8.5), taken out after 12 hours of reaction, washed and dried to obtain a polydopamine / polylactic acid composite membrane (PPDA).

[0048] Step 2: Add 5 parts by mass of chitin powder to 1 mol / L HCl aqueous sol...

Embodiment 2

[0052] Example 2: Preparation of self-assembled chitin whisker-modified polylactic acid composites

[0053] Step 1: Weigh 5.0 parts by mass of racemic polylactic acid (PDLLA) particles with a weight-average molecular weight of 20w, and pour it into 80 parts by volume of tetrahydrofuran to dissolve. After stirring and dissolving for 10 h, the solution was subjected to ultrasonic treatment for 10 min to remove air bubbles in the solution, and then poured into a polytetrafluoroethylene petri dish for molding. After volatilizing at room temperature for 24 h, it was put into a vacuum drying oven at 40° C. for vacuum drying for 6 h to completely remove the organic solvent, and a PDLLA film was obtained. The PDLLA membrane was immersed in a 1.5 g / L dopamine hydrochloride Tris buffer solution (pH=8.5), taken out after 6 hours of reaction, washed, and dried to obtain a polydopamine / polylactic acid composite membrane (PPDA).

[0054] Step 2: Add 10 parts by mass of chitin powder to 3 m...

Embodiment 3

[0060] Example 3: Preparation of self-assembled chitin whisker-modified polylactic acid composite film

[0061] Step 1: Weigh 2.0 parts by mass of racemic polylactic acid (PDLLA) particles with a weight-average molecular weight of 30w, and pour it into 40 parts by volume of dichloromethane to dissolve. After stirring and dissolving for 12 h, the solution was subjected to ultrasonic treatment for 15 min to remove air bubbles in the solution, and then poured into a PTFE petri dish for molding. After volatilizing at room temperature for 12 h, it was put into a vacuum drying oven at 40° C. for vacuum drying for 6 h to completely remove the organic solvent, and a PDLLA film was obtained. The PDLLA membrane was further immersed in a 3.0 g / L dopamine hydrochloride Tris buffer solution (pH=8.5), taken out, rinsed and dried after the reaction for 18 hours to obtain a polydopamine / polylactic acid composite membrane (PPDA).

[0062] Step 2: Add 8 parts by mass of chitin powder to 2 mol / ...

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Abstract

The invention belongs to the field of biological nano-composite materials and bone tissue repair materials, and discloses a layer-by-layer self-assembled chitin whisker-modified polylactic acid composite material and a preparation method and application thereof. The polylactic acid composite material of the present invention is composed of a substrate, an adhesive layer and a modified layer, the substrate is polylactic acid, the adhesive layer is polydopamine, and the modified layer is composed of positively charged chitin whiskers and The negatively charged chitin whiskers are alternately self-assembled layer by layer. The main feature is that the thickness and chargeability of the chitin whisker layer on the surface can be controlled, so that the mechanical properties of the composite material and the biological function of the surface can be flexibly regulated. The invention also provides a preparation method of the composite material. The composite material of the invention not only has good mechanical properties, excellent cell affinity, osteogenic activity and antibacterial properties, but also has adjustable mechanical properties and surface biological functionality, and is expected to have good properties in the biomedical fields such as bone tissue repair. application prospects.

Description

technical field [0001] The invention belongs to the field of biological nano-composite materials and bone tissue repair materials, and particularly relates to a layer-by-layer self-assembled chitin whisker-modified polylactic acid composite material and a preparation method and application thereof. Background technique [0002] Bone tissue defect is a common problem in orthopaedics and orthopaedics, and how to achieve efficient repair of bone tissue has become a hot topic in medical research. Among many bone repair methods, the use of bone repair materials to assist in the treatment of bone defects has been proved to be feasible. Polylactic acid (PLA) has been approved for clinical bone repair due to its good biocompatibility, degradable absorbability, and good processing properties. However, with the in-depth study of PLA materials, its limitations as bone repair materials have also become prominent, such as unsatisfactory mechanical properties and osteogenic activity. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/00A61L27/40A61L27/34A61L27/18A61L27/48A61L27/54C08L67/04
CPCC08J7/00A61L27/34A61L27/18A61L27/48A61L27/54A61L2430/02C08J2367/04C08J2405/08C08J2479/04
Inventor 罗丙红刘坤文伟周长忍
Owner JINAN UNIVERSITY
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