85results about How to "Controllable mechanical properties" patented technology

The invention belongs to the technical field of sealing materials and relates to a method for preparing polyurethane/rubber interpenetrating network type water-swellable rubber. The method comprises the following steps: firstly, mixing rubber and super-absorbent resin for 10 to 40 minutes in an open mill; further adding solid softener, colorant, anti-ager and promoter to the open mill, and mixing for 10 to 40 minutes; then, adding zinc oxide, reinforcing agent and plasticizer to the open mill, and mixing for 10 to 50 minutes; further adding vulcanizer to the open mill, and mixing to obtain a mixture A; evenly mixing polyethylene glycol and MDI (methyl-di-p-phenylene isocyanate) by equal molar weight to obtain a mixture B; blending the mixture A and the mixture B in the open mill to obtain a product; and finally, vulcanizing the product in a mold on a plate vulcanization machine with the temperature and pressure being respectively controlled at 150 to 160 DEG C and at 10MPa to 15MPa, to obtain the interpenetrating network type water-swellable rubber. The method of the invention has the advantages of simple preparation process, high product expansion ratio, high ion resistance and controllable water absorption rate and mechanical properties.

The invention belongs to the field of biomedical materials, and particularly relates to photo-curing hydrogel for multi-cell sorting and stem cell area-selecting differentiation and a preparation method thereof. The photo-curing hydrogel is prepared by taking modified high-polymer materials with the photo-curing performance as raw materials and are divided into multiple different areas by straight-stripe-shaped or net-stripe-shaped or annular-stripe-shaped micro-pattern structures, the hardness of the photo-curing hydrogel in the same area is same, the hardness of the photo-curing hydrogel in the different areas is same or different, and the overall photo-curing hydrogel at least has two kinds of the hardness. According to the photo-curing hydrogel for multi-cell sorting and stem cell area-selecting differentiation and the preparation method thereof, on one hand, the elasticity moduli of all the areas of the photo-curing hydrogel are different by controlling the ultraviolet radiation curing degree; on the other hand, all the areas with the different elasticity moduli present the micro-pattern structures on the photo-curing hydrogel, selective adhesion, proliferation and differentiation of cells on the photo-curing hydrogel can be achieved by combining the elasticity moduli with the micro-pattern structures, and therefore controllable cell sorting or stem cell area-selecting differentiation can be achieved.

The invention discloses an impact-resistant and high-energy-absorption lattice sandwich structure with a negative poisson ratio characteristic. The lattice sandwich structure is formed on the basis ofa high-performance negative poisson ratio lattice core material. The negative poisson ratio lattice core material is obtained by changing an included angle between a supporting column and a coordinate axis through a three-dimensional cubic structure. When the included angle between the supporting column and the coordinate axis is not equal to zero, the negative poisson ratio lattice core materialis obtained. The negative poisson ratio lattice material and two thin plates form a novel negative poisson ratio lattice sandwich structure, and the structure has the characteristics of a traditionalauxetic lattice structure and a traditional lattice sandwich structure at the same time, that is, the structure has the characteristics of the negative poisson ratio and the same-direction curvature;meanwhile, has excellent mechanical properties such as ultra-light weight, high specific modulus, high specific strength, impact resistance and high energy absorption. In addition, the sandwich structure has high adjustability, and the mechanical property of the lattice sandwich structure can be adjusted and controlled within a large range by adjusting the deflection angle of the supporting column and the relative density of the lattice material. The lattice sandwich structure has a great application prospect in the field of aerospace.

The invention provides a method for preparing large-size bulk amorphous composite materials, which belongs to the field of preparing amorphous alloy (metallic glass) and composite materials thereof. The method applies to superplastic diffusion bonding of bulk amorphous substances and fiber, and is characterized in that the bulk amorphous substances and the fiber are arranged in a certain mode (such as a layered mode and the like), put into a mold, pressurized and thermally insulated under gas protection or vacuum for superplastic diffusion bonding; pressure is released after a certain period of time; and workpieces are taken out of the mold. The invention also provides a novel device for preparing large-size bulk amorphous, fiber/amorphous composite materials through superplastic diffusion bonding. The device consists of a heating system, a heat insulation system, a mold system, a loading system, a gas protection system and a cooling system. The method and the device have the advantages of reinforcing the fiber, enabling the shape of amorphous alloy-base composite materials to be designed, enabling the volume of the fiber in the composite materials to be controlled and enabling the fiber to be used in other various amorphous alloy systems low in amorphous formation capability, and are applicable to armor boards, armor-piercing shells and the like.

The invention provides a collagen-based biomedical material by taking dialdehyde polyethylene glycol as a cross-linking agent and a preparation method thereof. The preparation method disclosed by the invention comprises the following steps of: preparing dialdehyde polyethylene glycol having a certain hydroformylation degree at first, uniformly mixing dialdehyde polyethylene glycol solution with the mass fraction of 0.1-5% with collagen solution with the mass fraction of 0.3-3%, then, pouring into a mould, freezing at -30-0 DEG C for 1-10 days, taking out, and freeze-drying in a freeze-drying machine for 1-2 days to obtain dialdehyde polyethylene glycol-collagen sponge; and repetitively immersing the sponge in water for 2-4 times, each time for 2-10 h to obtain dialdehyde polyethylene glycol-collagen hydrogel. According to the invention, a freezing polymerizing technology and a freeze drying technology are combined; the mechanical property, the thermal stability and the enzymatic degradation resistant property of collagen are improved by the prepared dialdehyde polyethylene glycol collagen sponge or gel; furthermore, the collagen-based biomedical material disclosed by the invention has the advantages of porosity, hydrophilia, water-retaining property, nontoxicity, good biocompatibility and the like, can be used in the biomedical fields, such as biological scaffolds, cell culture, drug release, burn and wound dressing and the like, and has good market application prospect.

The invention discloses a three-dimensional-structured silk fibroin/hydroxyapatite composite stent and a preparation method thereof. The preparation method of the three-dimensional-structured silk fibroin/hydroxyapatite composite stent comprises preparing silk fibroin/hydroxyapatite composite powder uniform in size through biomimetic mineralization; then through the three-dimensional printing technology, precisely controlling the appearance of the composite stent and the shape, size and connectivity of internal holes to obtain the special three-dimensional-structured silk fibroin/hydroxyapatite composite stent applicable to bone tissue engineering for facilitating cell growth and ossification. The three-dimensional-structured silk fibroin/hydroxyapatite composite stent has the advantage of achieving one stent in one structure and is a bone repair composite material stent high in porosity and pore connectivity and controllable in mechanical property, thereby being beneficial to osteogenic induction and differentiation and cell adhesion, migration and proliferation and capable of creating microenvironment meeting growth demands of osteoblasts. The three-dimensional-structured silk fibroin/hydroxyapatite composite stent is simple and practicable in preparation, low in process and equipment requirements, easy to control of experiment parameters and capable of promoting popularization and application of the three-dimensional printing technology in the biological field.

The invention relates to a porous elastic polyvinyl alcohol/bacterial nano-cellulose composite hydrogel tube, as well as a preparation method and application of the composite hydrogel tube. The composite hydrogel tube comprises a surface layer and a lining layer, wherein the surface layer has a smooth surface, and the lining layer is of a nano-fiber network structure. The preparation method comprises the following steps: pretreating the bacterial nano-cellulose composite hydrogel tube; preparing a polyvinyl alcohol solution; freezing at minus 80 DEG C for molding; unfreezing by ethanol at minus 20 DEG C; and soaking in ultrapure water at room temperature to replace the ethanol. The porous elastic polyvinyl alcohol/bacterial nano-cellulose composite hydrogel tube is controllable in mechanical performance and can meet the requirements of multiple tissue repairing stents, the nano-fiber network structure of the composite hydrogel tube is advantageous to cell adhesion and proliferation, and the mutually communicated porous structure of the composite hydrogel structure is advantageous to nutrition transmission and cell ingrowth; and the porous elastic polyvinyl alcohol/bacterial nano-cellulose composite hydrogel tube is simple in preparation process and low in cost, and has a good application prospect in vascular repairing stents and nerve repairing stents.

The invention discloses a 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and a preparation method thereof. The 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold is prepared accordingto the following steps: adopting a fusion extruding forming type 3D printing technology for extruding PCL and forming fiber bundles and preparing a 3D printed PCL scaffold through a splicing frameworkof the fiber bundles; forming a PDA coating by automatically polymerizing dopamine on the fiber surface of the 3D printed PCL scaffold, thereby preparing a 3D printed PCL-PDA scaffold; lastly, soaking the acquired 3D printed PCL-PDA scaffold in a BMP2 solution, thereby acquiring the 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold. The scaffold prepared according to the invention has theadvantages of simple and reliable structure, controllable appearance and microstructure, reliable mechanical properties and controllable ion release property, and can be used for restorative treatmentof bone trauma, bone tumors and bone defect after bone infection.

The invention discloses Al2O3 ceramic composite materials with a bionic structure and a preparation method thereof. The ceramic composite materials are in a multiple layers of structure and are formed by Al2O3 and metal Mo in an alternating overlapping mode, a surface layer is an Al2O3 layer, and a spacer layer is a metal Mo layer. After being alternatively overlapped in a graphite mold, Al2O3 powder and metal Mo powder are directly placed in a hot press furnace for hot pressing and sintering, and the Al2O3 ceramic composite materials are obtained. The Al2O3 ceramic composite materials are controllable in mechanical property (mainly breaking tenacity and bending strength), high in purity, excellent in high-temperature friction performance and capable of being used for lubricating and sealing materials in extremely severe environments (high temperature, corrosion, special atmosphere and the like).

The invention discloses a preparation method of an ultrathin high strength hydrogel membrane. The preparation method comprises the steps of mixing a hydrophilic monomer, a hydrophobic monomer, an initiator and a solvent A to obtain a mixed liquor, and performing free radical polymerization to obtain a random copolymer solution; and dripping the random copolymer solution into a solvent B, spreading on the surface of the solvent B to form an ultrathin high strength hydrogel membrane, wherein the solvent A is a single solvent or a mixed solvent capable of simultaneously dissolving the hydrophilic monomer, the hydrophobic monomer and the random copolymer, the solvent B is a poor solvent of the random copolymer and is a single solvent or a mixed solvent, and the solvent A and solvent B are much different in surface tension. The hydrogel membrane prepared by the method has the thickness of 10-200mu m, has good mechanical property, can be converted into sol and has repairable function under stimulation of pH, temperature and solvent, and can be used in the fields of medical wound dressing, separating membrane materials, facial mask base materials.

The invention discloses a preparation method of porous titanium and titanium alloy, and belongs to the technical field of porous metal materials. The preparation method of the porous titanium and titanium alloy with an anisotropic elongated pore structure suitable for bone tissue to grow in includes the steps that stearic acid, a binder and a titanium raw material are mixed evenly; the obtained mixture is subjected to press forming and then dried, and a pressed blank is obtained; the pressed blank is subjected to vacuum sintering and cooling, and the porous titanium or porous titanium alloy isobtained. By adjusting the mass ratio of the titanium raw material to stearic acid, adjusting the size of stearic acid and optimizing the forming pressure condition, control over the porosity, pore size and pore shape of the porous titanium and titanium alloy is realized, and the porous titanium and titanium alloy with an orderly elongated pore structure are obtained.

The invention discloses a method for preparing a cross-linked collagen/chitosan tissue engineering porous support in one-step freeze-drying mode, which uses natural biological material of collagen and chitosan as raw materials, directly adds collagen/chitosan mixed swelling solutions in a glutaraldehyde solution and prepares the collagen/chitosan tissue engineering porous support through a one-step refrigeration freeze-drying mode. The collagen/chitosan support prepared through the method has the advantages of being controllable in mechanical property, proper in degradation rate and good in biocompatiability. Further, the method only needs a one-step freeze-drying process and effectively solves the problems of support collapsing, micro-structure breaking and the like caused by a traditional preparing method. The method is simple and practical, low in energy consumption, time-saving, material-saving and good in repeatability, and the constructed collagen/chitosan porous support can be widely used in the field of tissue engineering and has good clinical application prospect.

The invention relates to a three dimensional (3D) printed PCL-PDA-AgNPs scaffold for anti-infective bone tissue engineering as well as a preparation method and application of the 3D printed PCL-PDA-AgNPs scaffold, belonging to bioengineered human implants. According to the method, poly(epsilon caprolactone) is used as a base material, polydopamine is used as a surface modification material, and silver nanoparticles with anti-infective biological properties are combined for use, so that the biological functions of anti-infection, bone growth promotion and bone defect repair are realized. The 3Dprinted PCL-PDA-AgNPs scaffold for the anti-infective bone tissue engineering has the advantages of being simple and reliable in structure, controllable in appearance and micro-structure, reliable inmechanical properties, controllable in ion release property, convenient in implantation, less in trauma and low in cost.

The invention provides a preparation method of a silk fibroin sericin composite membrane. The method comprises the following steps: (A) putting silk fibroin in warm water for pretreatment, then placing the silk fibroin in water at 65-95 DEG C, and conducting drying to obtain a pre-treated silk; (B) treating the initially-treated silk in a neutral salt solution, then purifying the obtained silk fibroin sericin composite solution, and obtaining a silk fibroin sericin composite solution; and (C) concentrating the silk fibroin sericin composite solution into a film, placing the obtained initial composite film in a small molecule monohydric alcohol for treatment, then conducting washing and drying, and obtaining the silk fibroin sericin composite film. According to the application, the silk fibroin sericin composite solution is prepared by adopting mild degumming and one-step dissolution method, the composite membrane prepared by the silk fibroin sericin composite solution has high strengthand high toughness, and the neck sticking technical problem of insufficient mechanical properties of tissue repair materials derived from natural biopolymers for hard tissue repair such as endocranium and dura mater, is solved.

The invention discloses an efficient directional radiation shielding protection structure and a 3D printing method thereof. The 3D printing method comprises the following steps that a first spray headis adopted for printing a base material to form a framework unit with a filling cavity; a filling reinforcing material is printed in the filling cavity of the framework unit through a second spray head; a fixing material is sprayed on the upper surface layer of the reinforcing material through a third spray head to form a thin film and solidify the thin film; and the steps are repeated until theprocessing is finished. According to the 3D printing method, through a framework unit structure, the defects of warping, deformation and the like in the large workpiece solid filling manufacturing process of a macromolecule single material are overcome, and the manufactured workpiece has high precision.

The invention discloses a method for modifying an extracellular matrix. Genipin or a derivate thereof is used as a cross-linking agent, and at least one of biological functionalization agent, pigment and chain extender, and the extracellular matrix are subjected to contact reaction. The method can realize the enhancement of the extracellular matrix and/or dyeing or bionic functionalization, the Genipin or the derivate thereof is used as the cross-linking agent, the chain extender, the biological functionalization agent and the like are introduced, and the aims of the controllable mechanical property of the modified extracellular matrix are fulfilled by controlling reaction conditions.

The invention discloses an electrode pile having a slope protection function and a use method thereof. The electrode pile comprises an electrode pile pair and a reinforced concrete pile, wherein the electrode pile pair comprises a plurality of sets of anode piles and cathode piles, the cathode piles and the anode piles are respectively connected to the two ends of the reinforced concrete pile, andthe cathode piles, the reinforced concrete pile and the anode piles are cyclically installed, and the length of the electrode piles is greater than that of a sliding surface of a soil body. The use method comprises the steps of making electrode piles, pressing the electrode piles, connecting a connection circuit to a power supply, and beginning to execute treatment. The effect of an electric field is fully utilized to prevent moisture from entering the deep part of the soil body and causing large-area landslide and enhance the structural stability of the soil body.

The invention discloses a 3D printing method of continuous fiber self-enhancement composite material. The 3D printing method comprises the following steps: at first, establishing a three-dimensional model of a self-enhancement composite material workpiece, and deriving the three-dimensional model as an stl formatted file; determining a printing temperature interval, wherein the self-enhancement composite material is thermoplastic high polymer material with different physical forms and is provided with a reinforced phase and a matrix base, the reinforced phase and the matrix base have the samechemical construction and different melting points, the reinforced phase is continuous fiber, and the matrix phase is resin; the printing temperature scope is higher than the melting point of the matrix phase and is lower than the melting point of the reinforced phase; preparing the self-enhancement composite material through 3D printing, finally, recycling the self-enhancement composite material,physically crushing the self-enhancement composite material, heating the crushed self-enhancement composite material to above the melting point to completely melt the self-enhancement composite material, and recycling the self-enhancement composite material as the raw material. On one hand, the 3D printing method solves the problems that the interfacial properties are poor and recycling is difficult when 3D printing is carried out on the composite material, and on the other hand, low-cost rapid manufacturing of the continuous fiber self-enhancement composite material is realized.

The invention provides a preparation method for a bionic composite bone scaffold. The preparation method comprises the following steps: A) placing silk into warm water for pretreatment, then placing the silk into water with a temperature of 65-95 DEG C for treatment, and carrying out drying so as to obtain primarily treated silk; B) treating the primarily treated silk into a neutral salt solution,and re-purifying an obtained silk fibroin and sericin composite dissolved solution so as to obtain a silk fibroin and sericin composite solution; and C) concentrating the silk fibroin and sericin composite solution, carrying out freeze-drying, placing an obtained initial skeleton into micromolecular monohydric alcohol for treatment, and carrying out freeze-drying so as to obtain the bionic composite bone scaffold. According to the invention, the silk fibroin and sericin composite solution is prepared by adopting a mild degumming and one-step dissolving method, and the bionic composite bone scaffold prepared by utilizing the silk fibroin and sericin composite solution has high strength, high modulus and high toughness; and the bionic composite bone scaffold solves the neck-clamping technical problem of insufficient mechanical properties of a natural biopolymer tissue engineering scaffold for bone regeneration and repair.