3D-printing PCL-PMMA-vancomycin anti-infection bone scaffold, and preparation method and application thereof

Abstract

The invention provides a 3D-printing PCL-PMMA-vancomycin anti-infection bone scaffold, and a preparation method and an application thereof and belongs to engineering human implants. In the method, poly-epsilon-caprolactone and polymethyl methacrylate serve as base materials and vancomycin serves as an anti-infection medicine, thus achieving biofunctions of anti-infection and promotion of osseointegration and bone defect filling surrounding the implant. The method includes: firstly, extruding PCL to form fiber bundles through a melting extrusive shaping 3D printing technology, and preparing a 3D-printing PCL scaffold by means of the jointing structure of different layers and angles of the fiber bundles; then under certain conditions, adding a PMMA monomer solution to a powder, and adding the vancomycin to the PMMA to prepare a PMMA-vancomycin mixture; filling the gaps in the 3D-printing PCL scaffold with the PMMA-vancomycin mixture in a semi-fluidized period, thereby forming the 3D-printing PCL-PMMA-vancomycin anti-infection bone scaffold. The bone scaffold has simple and reliable structure, controllable appearance and microstructure, reliable mechanical properties and controllability of medicine release performance. The bone scaffold is convenient to implant and is invasive-less and low-cost.

Description

technical field [0001] The invention relates to a 3D printed PCL-PMMA-vancomycin anti-infection bone scaffold and its preparation method and application, which belongs to a bioengineered implant in the human body and can be used to treat various pathogenic bacteria, such as Staphylococcus aureus , Streptococcus pyogenes, β-hemolytic streptococcus, Bacillus anthracis, Bacillus diphtheria, etc., for the treatment of acute and chronic osteomyelitis, septic arthritis bone destruction and the treatment of bone defects after infection. Background technique [0002] Infection is defined as a disruption of the balance between the host tissue and the local concentration of microorganisms, generally considered to be greater than 10 5 Each gram of tissue or the presence of pathogenic bacteria such as Staphylococcus aureus, Streptococcus pyogenes, and β-hemolytic streptococcus is considered to be an infection. Among many infectious diseases, bone and joint infection is not only a commo...

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Problems solved by technology

At the same time, these materials are expensive and the processing methods are complicated, so it is difficult to promote and apply them to a large number of patients in clinical applications.

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