The invention discloses a quaternary hypoeutectic high-entropy alloy excellent in strength and plasticity match. The quaternary hypoeutectic high-entropy alloy consists of a component of AlxCoyCrzNiw,wherein x, y, z and w respectively are molar ratios of corresponding elements, the molar ratios meet the relationships: 16>=x>=12, 30>=y>=26, 30>=z>=26, and 32>=w>=28. The quaternary hypoeutectic high-entropy alloy is of hypoeutectic structure, and excellent in strength and plasticity match. Simultaneously, the invention further provides a preparation method of the quaternary hypoeutectic high-entropy alloy. The preparation method includes: first, removing oxide skin from the elementary metals, weighing and mixing the elementary metals according to the molar ratios to obtain a mixture, placing the mixture in a high vacuum non-self-consuming arc melting furnace, performing electric arc melting in vacuum under argon protection, obtaining an alloy solution, stirring and cooling the alloy solution, obtaining an alloy ingot, repeating smelting for four times to obtain a high-entropy alloy, removing oxide skin from the obtained high-entropy alloy, performing ultrasonic cleaning twice by using ethyl alcohol, placing a clean alloy ingot in a high vacuum arc smelting rollover casting and centrifugation casting system, pouring molten alloy obtained after remelting into a copper mold, and then obtaining a high-entropy alloy test sample Al14Co28Cr28Ni30. The preparation method is simple, safe and stable.