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Method for preparing bioactive injectable hydrogel materials for oncotherapy

A technology of biologically active water and gel materials, which is applied in the field of preparation of injectable biologically active hydrogel materials, can solve the problems of poor drug treatment sensitivity, large toxic and side effects, and easy recurrence of trauma, avoiding toxic and side effects, high Effects of water content, good biocompatibility and biosafety

Active Publication Date: 2012-09-12
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, clinical drug chemotherapy, radiotherapy and surgery for tumors have disadvantages such as poor drug sensitivity, large toxic and side effects, large trauma and easy recurrence, so it is urgent to study new tumor treatment strategies

Method used

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  • Method for preparing bioactive injectable hydrogel materials for oncotherapy
  • Method for preparing bioactive injectable hydrogel materials for oncotherapy
  • Method for preparing bioactive injectable hydrogel materials for oncotherapy

Examples

Experimental program
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specific Embodiment approach 1

[0019] Specific Embodiment 1: The preparation method of the injectable bioactive hydrogel material used for tumor treatment according to this embodiment is carried out according to the following steps: 1. Prepare 10 mL of hyaluronic acid solution with a mass concentration of 2.5%, let it stand overnight, and then Add 0.25g of sodium periodate, avoid light, and oxidize on a shaking table at 4°C for 6 hours, then add 200 μL of ethylene glycol and oxidize on a shaking table for 2 hours, then add an equal volume of absolute ethanol, and precipitate out, which is oxidized hyaluronic acid 2. Add an equal volume of water to the oxidized hyaluronic acid to dissolve it, then put it into a 40KD dialysis bag, and dialyze it at 4°C for 48-72 hours, then freeze-dry it with a freeze dryer, and then use a volume concentration of 75% alcohol is used for disinfection, and after drying, it is prepared into an oxidized hyaluronic acid solution with a mass concentration of 8%; 3. Prepare an ADH so...

specific Embodiment approach 2

[0023] Embodiment 2: This embodiment differs from Embodiment 1 in that: in step 1, the rotating speed of the shaker is 30 r / min. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0024] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the molecular weight of hyaluronic acid in Step 1 is 10,000-100,000 Daltons. Others are the same as in the first or second embodiment.

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Abstract

A method for preparing bioactive injectable hydrogel materials for oncotherapy relates to the method for preparing the bioactive injectable hydrogel materials and is a novel strategy for the oncotherapy. The method for preparing the bioactive injectable hydrogel materials for the oncotherapy includes the following steps of (1) preparing transparent hyaluronic acid solution, adding sodium periodate and ethylene glycol, shaking table for oxidization, adding absolute ethyl alcohol for precipitating oxidized transparent hyaluronic acid; (2) adding water into the oxidized transparent hyaluronic acid, dialyzing, freeze-drying, sterilizing with alcohol, and preparing oxidized transparent hyaluronic acid solution; (3) preparing ADH (antidiuretic hormone) solution, mixing the same with the oxidized transparent hyaluronic acid solution after being filtered, adding anti-cripto monoclonal antibody and active peptide, and mixing to obtain the hydrogel materials. By the method for preparing the bioactive injectable hydrogel materials for the oncotherapy, the prepared hydrogel materials are provided with high moisture content, loose and porous structures, nutriment intake, metabolic waste metabolic waste and air exchange are facilitated, and the mechanical property is controllable. The method for preparing the bioactive injectable hydrogel materials for the oncotherapy is used for the field of the oncotherapy.

Description

technical field [0001] The invention relates to a preparation method of an injectable bioactive hydrogel material. Background technique [0002] The current mechanisms to explain tumorigenesis mainly focus on genetic material changes, oxidative stress, and epigenetic mechanisms. However, more and more people realize that the occurrence of tumor is a systemic disease, that is, tumor system biology. In addition to the above mechanisms, the abnormal growth of tumor is affected by the interaction between tumor cells and between cells and extracellular matrix. . A large number of research results have shown that tumor cells and embryonic stem cells have the same pluripotent phenotype and plasticity, and the embryonic microenvironment can reverse the malignant phenotype of tumor cells. The glycosylphosphatidylinositol-linked membrane protein Cripto I, which is highly expressed in tumor cells but not expressed in normal tissue cells, acts as a receptor for the morphogenic protein...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K39/395A61K47/48A61P35/00C08B37/08A61K38/02
Inventor 田维明闫宏吉李钰
Owner HARBIN INST OF TECH
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