3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and preparation method thereof

A technology of PCL-PDA-BMP2 and bone tissue engineering, applied in the field of bioengineered human implants, can solve the problems of pathogen transmission, immune rejection, and repeated large-scale use, so as to promote the formation of new bone tissue and promote ingrowth Effect

Inactive Publication Date: 2018-11-30
NANJING FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Including: 1. Autologous bone transplantation, which is limited by the limitation of its own donors and cannot be used repeatedly in large quantities; 2. Allogeneic bone transplantation, which mainly has problems such as immune rejection, pathogen transmission, and high co

Method used

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  • 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and preparation method thereof
  • 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and preparation method thereof
  • 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0038] Example 1

[0039] 1. Preparation of 3D printed PCL scaffold

[0040] The PCL is heated to 100°C to become liquid through a heating system of Fused Deposition Modeling (FDM) 3D printing. The formed fiber bundle is extruded, and the fibers are formed by intersecting and accumulating in the range of 0-180°, and finally form a 3D printed PCL scaffold with regular pores including a diamond structure of 0-45-90-135-180° ( figure 2 , 4 B). Its shape can be 3D printed and customized according to different bone defect shapes in the area to be repaired, or it can be manufactured as a fixed shape scaffold material by FDM 3D printing, and filled according to the actual bone defect requirements during the operation.

[0041] 2. Preparation of 3D printed PCL-PDA stent

[0042] After the PCL structure of the stent is constructed by 3D printing, the PDA is used for surface modification. The specific steps include:

[0043] 1) Prepare a hydrochloric acid (HCL) solution with a concentration of...

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Abstract

The invention discloses a 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and a preparation method thereof. The 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold is prepared accordingto the following steps: adopting a fusion extruding forming type 3D printing technology for extruding PCL and forming fiber bundles and preparing a 3D printed PCL scaffold through a splicing frameworkof the fiber bundles; forming a PDA coating by automatically polymerizing dopamine on the fiber surface of the 3D printed PCL scaffold, thereby preparing a 3D printed PCL-PDA scaffold; lastly, soaking the acquired 3D printed PCL-PDA scaffold in a BMP2 solution, thereby acquiring the 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold. The scaffold prepared according to the invention has theadvantages of simple and reliable structure, controllable appearance and microstructure, reliable mechanical properties and controllable ion release property, and can be used for restorative treatmentof bone trauma, bone tumors and bone defect after bone infection.

Description

technical field [0001] The invention belongs to the field of bioengineered human implants, and relates to a 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and a preparation method thereof. Background technique [0002] Clinically, bone defects caused by bone trauma, bone tumors, and bone infections are very common. Every year, a large number of patients with bone tissue defects in my country need surgical treatment. Finding bone tissue engineering repair materials with good biological properties has always been a hot spot in orthopedic research. How to find more and better bone tissue regeneration repair materials to repair human life and recreate health has become the common pursuit and tireless pursuit of many scientists around the world. research impetus. [0003] Although there are many treatments for bone defect repair, these methods generally have many problems such as few sources, many complications, immune rejection and iatrogenic infection, especially for...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/34A61L27/50A61L27/56A61L27/58B33Y10/00B33Y70/00
CPCA61L27/18A61L27/34A61L27/50A61L27/56A61L27/58A61L2300/252A61L2300/412A61L2300/602A61L2400/18A61L2420/02A61L2420/06A61L2430/02B33Y10/00B33Y70/00C08L67/04C08L79/02C08L89/00
Inventor 王黎明姚庆强徐燕于一帆
Owner NANJING FIRST HOSPITAL
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