3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and preparation method thereof

Abstract

The invention discloses a 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and a preparation method thereof. The 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold is prepared accordingto the following steps: adopting a fusion extruding forming type 3D printing technology for extruding PCL and forming fiber bundles and preparing a 3D printed PCL scaffold through a splicing frameworkof the fiber bundles; forming a PDA coating by automatically polymerizing dopamine on the fiber surface of the 3D printed PCL scaffold, thereby preparing a 3D printed PCL-PDA scaffold; lastly, soaking the acquired 3D printed PCL-PDA scaffold in a BMP2 solution, thereby acquiring the 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold. The scaffold prepared according to the invention has theadvantages of simple and reliable structure, controllable appearance and microstructure, reliable mechanical properties and controllable ion release property, and can be used for restorative treatmentof bone trauma, bone tumors and bone defect after bone infection.

Description

technical field [0001] The invention belongs to the field of bioengineered human implants, and relates to a 3D printed PCL-PDA-BMP2 bone tissue engineering scaffold and a preparation method thereof. Background technique [0002] Clinically, bone defects caused by bone trauma, bone tumors, and bone infections are very common. Every year, a large number of patients with bone tissue defects in my country need surgical treatment. Finding bone tissue engineering repair materials with good biological properties has always been a hot spot in orthopedic research. How to find more and better bone tissue regeneration repair materials to repair human life and recreate health has become the common pursuit and tireless pursuit of many scientists around the world. research impetus. [0003] Although there are many treatments for bone defect repair, these methods generally have many problems such as few sources, many complications, immune rejection and iatrogenic infection, especially for...

AI Technical Summary

Problems solved by technology

Including: 1. Autologous bone transplantation, which is limited by the limitation of its own donors and cannot be used repeatedly in large quantities; 2. Allogeneic bone transplantation, which mainly has problems such as immune rejection, pathogen transmission, and high cost; 3. Various Artificial bone substitute materials made of metals, ceramics or polymers have been used clinically, but most of them are used as permanent implants. They cannot participate in the metabolism of the human body, so the long-term effect is often unsatisfactory

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