Application of agrimonolide in antagonizing myocardial cell injury caused by hypoxia

Abstract

The invention discloses application of agrimonolide in antagonizing myocardial cell injury caused by hypoxia. The research results show that agrimonolide can protect myocardial cells damaged by hypoxia through promoting myocardial cell proliferation, inhibiting apoptosis caused by anoxia, maintaining the integrity of cell morphology and enhancing the function of mitochondria, and theoretical support is provided for development of new drugs for treating myocardial infarction.

Description

technical field [0001] The invention belongs to the field of medical application of agrilide, in particular to the medical application of agrilide in antagonizing myocardial cell injury caused by hypoxia. Background technique [0002] Hypoxia refers to the pathological process of abnormal changes in tissue metabolism, function and morphological structure due to insufficient oxygen supply or oxygen dysfunction. Hypoxia is a very common pathological process in various clinical diseases, which can damage cardiomyocytes and induce apoptosis. Myocardial infarction (MI) is a common clinical cardiovascular disease caused by acute and persistent ischemia or hypoxia of the heart. Although great progress has been made in the treatment of MI, the morbidity and mortality of myocardial infarction are still high, seriously threatening human health. Apoptosis and injury of cardiomyocytes are the main features of MI. Therefore, finding an effective new drug to reduce myocardial cell injur...

AI Technical Summary

Problems solved by technology

Although the treatment of MI has made great progress, the morbidity and mortality of myocardial infarction are still high, which seriously threatens human health.

However, there is no report on the effect of agrilactone on hypoxia-induced cardiomyocyte injury

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