Diagnostic kit and diagnostic method

A diagnostic kit and diagnostic method technology, applied in the direction of disease diagnosis, biological testing, material inspection products, etc., to achieve the effect of being convenient for clinical use, avoiding human error, and objective test results

Inactive Publication Date: 2020-09-04
FOSHAN DIAN MEDICAL LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies of the prior art, the present invention

Method used

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  • Diagnostic kit and diagnostic method
  • Diagnostic kit and diagnostic method
  • Diagnostic kit and diagnostic method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1, For women >35 years old who have failed to conceive for half a year or have a high risk of ovarian reserve reduction (such as cancer treatment or ovarian surgery history, etc.) Notes: Poor ovarian reserve function test results (low AMH value) do not mean infertility , cannot be used as a separate criterion to refuse reproductive treatment. Reasonable advice to patients is: the chance of pregnancy may be less than expected, and early conception is encouraged.

Embodiment 2

[0050] Example 2, through the predictive role of AMH in assisted reproductive technology (ART), patients can be correctly evaluated, and an ideal individual treatment plan can be formulated, which can increase the pregnancy rate and reduce the risk factors of complications to a certain extent.

Embodiment 3

[0051] Example 3, as a sign of small antral follicles, AMH can also be used to prompt the severity of PCOS, and the therapeutic effect can be evaluated by detecting different time points in the course of treatment (insulin sensitizer metformin can reduce the number of ovarian cystic follicles in PCOS patients, Reduce the concentration of AMH in serum), also can predict whether menstruation will return to normal after weight loss.

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Abstract

The invention discloses a diagnostic kit and a diagnostic method. The composition comprises the following components: anti-mullerian hormone (AMH), assisted reproduction (ART), ovarian granuloma (GCT)and sinus follicle count (AFC), and the anti-mullerian hormone (AMH) is one of members of a transforming growth factor beta superfamily and is generated by recruitment of granulocytes of presinus follicles and small sinus follicles. The invention relates to the technical field of diagnostic kits. According to the diagnostic kit and the diagnostic method, AMH is not influenced by the menstrual cycle, the serum AMH level does not fluctuate obviously in the whole menstrual cycle, the kit can detect and measure the AMH level at any time and can relatively truly reflect the stock condition of original follicles and avoids the troubles and personal errors of sinus follicles (AFC) counting under B-ultrasonic waves and is more objective and accurate in detection result and is not affected by hormone contraceptives or exogenous hormones and is convenient for clinical use.

Description

technical field [0001] The invention relates to the technical field of diagnostic kits, in particular to a diagnostic kit and a diagnostic method. Background technique [0002] Anti-Müllerian hormone (AMH) is secreted by granulosa cells in preantral and small antral follicles, but not by dominant follicles12. Anti-Müllerian hormone in polycystic ovary syndrome (PCOS) refers to lesions characterized by menstrual disorders, persistent ovulation disorders, hyperandrogenism, and polycystic ovaries. Studies have pointed out that anti-Müllerian hormone (AMH) is a regulatory factor in the ovary. It is currently recognized that it is related to follicular growth and atresia, and even participates in the occurrence of hyperandrogenism. It is mainly affected by anti-Mullerian hormone. body. [0003] The main physiological role of anti-Müllerian hormone (AMH) is to inhibit the recruitment and growth of follicles and prevent the excessive depletion of follicle pools. The level of AMH ...

Claims

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Application Information

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IPC IPC(8): G01N33/74G01N33/574G01N33/50
CPCG01N33/5005G01N33/57449G01N33/57484G01N33/74G01N2333/575G01N2800/36
Inventor 唐菁娟
Owner FOSHAN DIAN MEDICAL LAB
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