Prediction method of mutation site of virus adaptive to human host, and application thereof

A mutation site, virus technology, applied in the fields of viral genetics and cell biology
CN111663009APending Publication Date: 2020-09-15BEIJING INST OF GENOMICS CHINESE ACAD OF SCI CHINA NAT CENT FOR BIOINFORMATION
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING INST OF GENOMICS CHINESE ACAD OF SCI CHINA NAT CENT FOR BIOINFORMATION
Publication Date
2020-09-15

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Abstract

The invention discloses a prediction method of a mutation site of virus adaptive to a human host, and application thereof, and in particular relates to adaptive mutation of virus adaptive to a human host, and application thereof as a drug target and a biomarker. The fact that animal host coronavirus exists in a target attacked by human lung tissue miRNA is found for the first time in the invention; human coronavirus loses targets on these genome through the adaptive mutation so as to get the capability of spreading in the human host; the site of the coronavirus adaptive mutation provided by the invention can be used as a drug design target for treating or preventing coronavirus infection, and a biomarker for checking the coronavirus host range; simultaneously, the algorithm for predictingthe target attacked by the host miRNA on the virus genome provided by the invention can be used for predicting RNAi sensitive targets of all kinds of virus; and the drug design target for treating andpreventing corresponding virus infection and the host range checking biomarker are developed.
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Description

technical field

[0001] The invention relates to the fields of viral genetics and cell biology, in particular to a method for predicting mutation sites of viruses adapting to human hosts and its application. Background technique

[0002] SARS-CoV-2 (or hCov-19) is the causative virus of COVID-19. SARS-CoV-2 is the seventh known human-hosted virus in the genus Coronavirus. The other six diseases include SARS and MERS, which cause severe acute respiratory syndrome, and four (OC43, 229E, NL-63, and HKU-1) viruses that often cause mild respiratory infections with common cold-like symptoms. In addition to humans, the hosts of coronaviruses include a variety of mammals, and most human coronaviruses are thought to have originated from bat-hosted strains. However, there are still many unknowns about the mechanism of coronavirus migration between different hosts and what adaptive mutations in its genome lead to its adaptation to spread in the human population.

[0003] As a positiv...

Claims

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