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Genome variable comprehensive screening method

A screening method and genomic technology, applied in the fields of genomics, proteomics, instruments, etc.

Active Publication Date: 2020-10-02
DALIAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Using it for complex biological datasets has its limitations

Method used

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  • Genome variable comprehensive screening method
  • Genome variable comprehensive screening method
  • Genome variable comprehensive screening method

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Experimental program
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Embodiment Construction

[0055] In the following, a hypothetical data set is constructed in combination with the technical solution to further illustrate the specific implementation manner of the present invention. Assume that there are 10 samples of genomic data, including two categories (1 and 2), and a total of 6 gene variables: f 1 , f 2 , f 3 , f 4 , f 5 and f 6 .

[0056] Variable evaluation and screening:

[0057] (1) Calculate the difference score of the gene. Using formulas (1)-(5), calculate the non-overlapping degree of each gene, assuming f 1 , f 2 , f 3 , f 4 , f 5 and f 6 The non-overlapping degrees of are 0.9, 0.8, 0.8, 0.6, 0.5, 0.4 respectively, set α=0.8, according to the formula (6), the difference score of each gene can be obtained, DS 1 =0.9,DS 2 =DS 3 =0.8,DS 4 =DS 5 =DS 6 =0.

[0058] (2) Using the correlation between genes to calculate the influence of each gene. The correlation between hypothesized genes is shown in the table below:

[0059] Table 1. Corre...

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Abstract

The invention provides a genome variable comprehensive screening method, and belongs to the technical field of genome data analysis. According to the method, the distinguishing capability of genes ismeasured by adopting the non-overlapping degree, the influence of the genes is obtained through the correlation between the genes, and the importance of a community where the genes are located is considered. The importance of the genes is evaluated by integrating multiple indexes, and the gene set is screened for subsequent research of gene markers.

Description

technical field [0001] The invention belongs to the technical field of genome data analysis. The invention combines the actual characteristics of genome data with many variables, noise, and synergy between variables under the current high-throughput technology, and analyzes the data in the genome from the single-molecule level, molecular interaction level, and network level. It is a method of comprehensive evaluation and screening of genomic variables, which is helpful for the detection of subsequent cancers and the exploration of cancer mechanisms. Background technique [0002] In the 21st century, bioinformatics has developed rapidly. Bioinformatics is an emerging discipline combining computer science and biology. It mainly studies the collection, storage, analysis and interpretation of biological information, and reveals the mysteries of life hidden behind biological big data through the comprehensive use of computer technology and biological technology. In the field of ...

Claims

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Application Information

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IPC IPC(8): G16B20/00G16B20/20G16B40/00
CPCG16B20/00G16B20/20G16B40/00
Inventor 林晓惠亓彦鹏李超
Owner DALIAN UNIV OF TECH