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Camellia oil antisepsis and anti-inflammation gel and preparation method thereof

An antibacterial and anti-inflammatory, camellia oil technology, which is applied in antibacterial drugs, pharmaceutical formulas, medical preparations with non-active ingredients, etc., can solve problems such as exacerbation of the disease, clogged pores of the baby's skin, excessive use of talcum powder or skin care oil, etc.

Inactive Publication Date: 2020-10-23
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, parents who are first-time parents are often inexperienced. How much talcum powder or skin care oil is used will instead cause the baby's skin pores to be blocked and aggravate the condition

Method used

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  • Camellia oil antisepsis and anti-inflammation gel and preparation method thereof
  • Camellia oil antisepsis and anti-inflammation gel and preparation method thereof
  • Camellia oil antisepsis and anti-inflammation gel and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 clinical efficacy experiment

[0023] In order to clarify the curative effect of Camellia Oil antibacterial and anti-inflammatory gel drug composition of the present invention, for further confirming its curative effect, carried out corresponding clinical trial, the result is as follows:

[0024] ①Observe 80 cases of children with diaper rash, aged 1 month to 1 year, with an average of 4.2 months; 34 cases of male infants and 46 cases of female infants. According to the admission registration number, they were divided into single and double groups, the odd number was the experimental group, and the even number was the control group, with 40 cases in each group.

[0025] ②The experimental group received camellia oil antibacterial and anti-inflammatory gel (20 parts of camellia oil, 1 part of comfrey extract, 0.5 part of aloe vera gel freeze-dried powder, 0.25 part of green tea extract), and the control group received Johnson's buttock cream. Apply to the af...

Embodiment 2

[0037] The investigation of embodiment 2 surfactants

[0038] Surfactant is the key to the uniform mixing of oil and water. Natural polymer emulsifiers (gum Arabic + tragacanth gum), anionic surfactants (sodium lauryl sulfate), non-ionic surfactants (polysorbate 40, polysorbate 60, polysorbate 80 and PEG-40 hydrogenated castor oil) to prepare emulsion, take the stability of the emulsion as the investigation index, and screen out the best emulsifier type by calculating the emulsion layer retention rate and its appearance properties . It can be seen from the experiment that there is no color change in the cold resistance test; after heat resistance, except polysorbate 80 and PEG-40 hydrogenated castor oil, the others all have oil layers or oil droplets, and PEG-40 hydrogenated castor oil and Tween 80 have a slight surface dry phenomenon. Ultimately it is preferred that polysorbate 80 is the surfactant of the present invention. The results are shown in Table 2.

[0039] The i...

Embodiment 3

[0041] The investigation of embodiment 3 gel matrix

[0042]Gel matrix is ​​one of the key factors for the formation of latex gels. The appearance of tragacanth gum, sodium carboxymethylcellulose CMC-NA, gelatin, sodium alginate and carbomer at 1% concentration after swelling for 24 hours was investigated respectively. Properties, spreadability and viscosity (gelatin and tragacanth gum are measured with No. 2 rotor, 60r / min; others are measured with No. 4 rotor, 12r / min). Using Carbomer 940 as the gel matrix, the product obtained has moderate viscosity and can be spread quickly. Ultimately it is preferred that Carbomer 940 is the gel matrix of the present invention. The results are shown in Table 3.

[0043] Table 3 Performance investigation of different gel matrices

[0044]

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Abstract

The invention discloses a camellia oil antisepsis and anti-inflammation gel, which is mainly prepared from camellia oil, radix arnebiae extracts, aloe gel freeze-dried powders and green tea extracts.Accordingly, an inventor also establishes a corresponding preparation method. Researches indicate that the camellia oil antisepsis and anti-inflammation gel prepared from the extraction solutions of various medicines has the functions of resisting bacteria, diminishing inflammation, resisting eczema, quickening skin tissues to be repaired and the like, has a good function for alleviating, repairing and preventing infant diaper rashes, and can effectively eliminate infant diaper rashes and prevent diaper dermatitis, even infantile eczema and the like. In addition, the camellia oil antisepsis and anti-inflammation gel has a simple product preparation technology, moderate product properties, good stability and high safety, is clear, moist and nutrient, has a pleasant smell, is convenient to use, and is suitable in the four seasons.

Description

technical field [0001] The invention belongs to the technical field of antibacterial and anti-inflammatory traditional Chinese medicine for external use, and in particular relates to a camellia oil anti-bacterial and anti-inflammatory gel and a preparation method thereof. Background technique [0002] Baby red buttocks (red buttocks) are called diaper rash and diaper dermatitis in medicine. They are skin diseases caused by diaper coverage. They are common and frequently-occurring diseases of infant skin. Almost all babies have experienced red buttocks . Its clinical manifestations are local erythema, papules, and blisters, which sometimes spread to the lower abdomen and thighs that can be covered by diapers, and in severe cases, superficial ulcers are formed. [0003] There are two main reasons for red buttocks: 1. The baby's skin is soft, the cuticle is very thin, and the skin cells are not tightly connected, resulting in poor skin defense function; 2. The baby's digestive...

Claims

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Application Information

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IPC IPC(8): A61K36/886A61K36/896A61K9/06A61K47/26A61P17/00A61P31/04
CPCA61K9/0014A61K9/06A61K36/30A61K36/82A61K36/886A61K36/896A61K47/26A61P17/00A61P31/04A61K2300/00
Inventor 冯秋瑜梁秋云黄慧学
Owner GUANGXI UNIV OF CHINESE MEDICINE
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