Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Application of thymosin or derivative thereof and medicine for treating depression

A technology of thymosin and derivatives, applied in the field of pharmacy, can solve the problems of death, acute poisoning, difficulty and so on

Active Publication Date: 2020-10-27
SHENZHEN INST OF GUANGDONG OCEAN UNIV
View PDF6 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the drugs used to treat depression are mainly monoamine reuptake inhibitors, such as bupropion, duloxetine, fluoxetine, etc., but these drugs can cause tachycardia, drowsiness, and constipation , dysuria, urinary retention and other serious cardiovascular side effects, and overdose can cause acute poisoning or even death

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of thymosin or derivative thereof and medicine for treating depression
  • Application of thymosin or derivative thereof and medicine for treating depression
  • Application of thymosin or derivative thereof and medicine for treating depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] 1. Experimental animals

[0026]Sexually mature female C57BL / 6 mice, body weight (20-22 g), were purchased from Shandong Experimental Animal Center (animal quality certificate: No. 37009200018914, license number: SCXK (Lu) 2014000). Breeding environment: 4 mice per cage, 22±1°C temperature, 50±10% humidity, 12h light-dark cycle, free to eat and drink. The feeding and operation of experimental animals complied with the relevant regulations on the feeding and use of experimental animals of Guangdong Ocean University.

[0027] Thymosin β4: purchased from Guangzhou Binshang Biotechnology Co., Ltd.

[0028] Rats and mice maintained powder feed: provided by Guangdong Experimental Animal Center.

[0029] Behavioral instruments: Shanghai Xinruan Information Technology Co., Ltd.

[0030] 2. Experimental plan

[0031] After the animals were repurchased and adapted to the laboratory for one week, they were randomly numbered and grouped into 3 groups, as shown in Table 1:

[0...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of pharmacology, discloses an application of thymosin or a derivative thereof and a medicine for treating depression, and particularly discloses an application of the thymosin or the derivative thereof in preparation of the medicine for treating the depression. The invention also discloses a pharmaceutical composition for treating the depression, and the pharmaceutical composition comprises a treatment effective dose of the thymosin or the derivative thereof. In the technical scheme of the invention, the systemic administration of the thymosin or the derivative thereof, especially thymosin [beta]4 or a derivative thereof, is safe, and the thymosin or the derivative thereof has a good curative effect on the depression and is tolerated by animals includinghuman beings.

Description

technical field [0001] The application relates to the field of pharmacology, specifically, the application of thymosin and its derivatives and the medicine for treating depression. Background technique [0002] Depression is a common mental illness with main symptoms: low mood, loss of interest in things, anhedonia; hopelessness and helplessness; anxiety; sleep and appetite disorders; memory loss and poor learning ability; severe cases may even commit suicide tendencies or behaviors. The core symptoms are anhedonia and helpless behavior. According to data from the World Health Organization, the number of depression patients worldwide exceeds 340 million, and the number of depression patients in China is nearly 100 million, and the incidence rate is significantly higher than that in foreign countries. Depression is expected to become the second leading disease worldwide by 2020. Although medicine has certain treatment measures for depression, due to the complex pathologica...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/22A61P25/24
CPCA61K38/2292A61P25/24
Inventor 宋采张才李晓红张永平张翼
Owner SHENZHEN INST OF GUANGDONG OCEAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com