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Pharmaceutical composition containing gentisic acid and application of pharmaceutical composition

A technology of gentisic acid and composition, which is applied in the field of natural polyphenols to achieve the effects of improving glucose tolerance and insulin resistance

Inactive Publication Date: 2020-11-10
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the prior art, the effects of compounding gentisic acid and Cabernet Sauvignon grape pomace extract to promote body heat production, resist obesity, and improve insulin resistance have not yet been reported.

Method used

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  • Pharmaceutical composition containing gentisic acid and application of pharmaceutical composition
  • Pharmaceutical composition containing gentisic acid and application of pharmaceutical composition
  • Pharmaceutical composition containing gentisic acid and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 High-fat and high-sugar diet-induced inhibition verification test of body obesity

[0041] Unless otherwise specified, the C57BL / 6J mice used in the following examples were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.; the gentisic acid and glucose used were chromatographically pure and purchased from Sigma Aldrich (Shanghai) Trading Co., Ltd. Company; the used Cabernet Sauvignon grape pomace extract is derived from the powder of Cabernet Sauvignon grape pomace after ethanol extraction, macroporous resin chromatography and freeze-drying, in which the total sugar content is 16.1mg / g, the total protein is 13.1mg / g g, fat 9.88mg / g, moisture 43.31mg / g, total phenols 604.11mg / g; the insulin used is biosynthesized human insulin commercially obtained from regular channels.

[0042] In order to verify the anti-obesity effects of gentisic acid and cabernet sauvignon grape pomace extract, the present invention fed C57BL / 6J mice with high...

Embodiment 2

[0049] Example 2 Verification Test of Body's Glucose Tolerance and Insulin Resistance Induced by High Fat and High Sugar Diet

[0050] Obesity is often accompanied by disturbances in glucose homeostasis, resulting in glucose tolerance and insulin resistance. Therefore, the present invention has carried out the following tests to the mice of each test group in the 10th week of administration in embodiment 1:

[0051] 1. Intraperitoneal glucose tolerance test (intraperitoneal glucose tolerance test, IGTT): the mouse after 11 weeks of administration in Example 1 was fasted for 16 hours, and the glucose of 1.5g / kg body weight was injected intraperitoneally after weighing, respectively Blood glucose was measured at 0min, 15min, 30min, 60min, 90min and 120min.

[0052] Such as image 3 As shown in middle 3-1, with the prolongation of time after glucose injection, the blood glucose of mice in the high-fat control group increased rapidly, while the compound treatment group of gentis...

Embodiment 3

[0057] Embodiment 3 body heat production test

[0058] The mice treated for the 10th week in Example 1 were placed in room temperature (25°C) and cold stimulation (4°C) environments for 3h respectively, and the body temperature of the mice was measured; using Cooled Incubator / LabMaster (TSE company) software, the energy of the mice was monitored for 24h level of spending.

[0059] The result is as Figure 5 As shown in middle 5-1, the compound treatment group of gentisic acid and cabernet sauvignon grape pomace extract enhanced the body heat production of mice in a cold environment, and was determined by Figure 5 It can be seen from middle 5-2 that compared with the high-fat control group mice, the compound treatment group of gentisic acid and cabernet sauvignon grape skin extract can promote the oxygen consumption level of mice to increase by 6.88%, 6.48% and 11.66% , which indicated that the compound treatment group of gentisic acid and cabernet sauvignon grape pomace ext...

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Abstract

The invention belongs to the field of health-care products, and particularly relates to a pharmaceutical composition containing gentisic acid and application of the pharmaceutical composition. The composition comprises the effective components of the gentisic acid and cabernet sauvignon pomace extract, wherein the mass percentage of the effective components is 0.3-1.2 wt%, and the balance is a pharmaceutically acceptable carrier; and in the effective components, the mass percent ratio of the gentisic acid to the cabernet sauvignon pomace extract is 1: 5. The application of the pharmaceutical composition containing the gentisic acid and the cabernet sauvignon pomace extract is used for treating obesity and related diseases. According to the obtained pharmaceutical composition, the effectivecomponents of the gentisic acid and the cabernet sauvignon pomace extract can effectively inhibit body obesity caused by high-fat and high-sugar diet and improve glucose tolerance and insulin resistance of the body, so that a new treatment way is opened up for treatment of the obesity and related diseases.

Description

technical field [0001] The invention relates to the field of natural polyphenols, in particular to a medicinal composition containing gentisic acid and cabernet sauvignon grape pomace extract and its application in health food. Background technique [0002] Over the past half century, obesity has become a prevalent chronic disease worldwide. At present, there are 1.9 billion overweight adults in the world, and 609 million adults are obese. Overweight and obese people account for 39% of the total population, and it is expected that the prevalence of obesity and overweight will continue to rise in the next 20 to 30 years. Both are still a major public health burden that needs to be faced worldwide. Epidemiological studies have shown that overweight and obesity are important risk factors for diabetes, hypertension, cardiovascular disease, cancer and premature death. Therefore, prevention and treatment of overweight and obesity and related complications have become a public hea...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P3/04A61P5/50A61K31/192
CPCA61K31/192A61K36/87A61P3/04A61P5/50A61K2300/00
Inventor 黄卫东韩雪郭杰龙游义琳战吉宬
Owner CHINA AGRI UNIV
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