A kind of traditional Chinese medicine composition and its application

A composition and drug technology, applied in the field of medicine, can solve the problems of lack of yin nourishing, qi tonifying drugs, poor compliance, etc., and achieve the effect of delaying the process of pulmonary fibrosis and improving the life span

Active Publication Date: 2021-10-08
ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The compatibility of Qingfei Mixture is mainly attacking, clearing, and purging, and it lacks Yin-nourishing and Qi-tonifying medicines. The low immunity of modern people is usually due to Qi and blood problems in the sub-health state, so it is not suitable for patients with low immunity, especially in the later stage. fibrosis patients
At the same time, Qingfei Mixture is prepared by decocting, and the patient's compliance with taking it is poor.

Method used

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  • A kind of traditional Chinese medicine composition and its application
  • A kind of traditional Chinese medicine composition and its application
  • A kind of traditional Chinese medicine composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Preparation of Qingfei Oral Liquid (water extraction)

[0037] Weigh 12 g of Zhebei, 15 g of Hedyotis diffusa, 15 g of Solanum nigrum, 5 g of Chonglou, 15 g of Scutellaria barbata, 12 g of Adenophora, 8 g of Prunella vulgaris, 15 g of Lily, and 15 g of Radix Polygonatum. Add 8 times the amount of water (896 ml) to the distillation bottle, soak for 1 hour, reflux at 180°C for 1.5 hours, filter to obtain the filtrate, add 8 times the amount of water to the dregs, and reflux at 180°C for 1.5 hours for the second time, filter The filtrate was obtained, and the two filtrates were combined and rotary evaporated to a volume of 896 ml.

Embodiment 2

[0038] Example 2: Qingfei Oral Liquid (alcohol extraction)

[0039] Weigh 12 g of Zhebei, 15 g of Hedyotis diffusa, 15 g of Solanum nigrum, 5 g of Chonglou, 15 g of Scutellaria barbata, 12 g of Adenophora, 8 g of Prunella vulgaris, 15 g of Lily, and 15 g of Radix Polygonatum. Add 8 times the amount (896 ml) of 50% alcohol to the distillation bottle, soak for 1 hour, reflux at 180°C for 1.5 hours, filter to obtain the filtrate, add 8 times the amount of 50% alcohol to the dregs, and keep the temperature at 180°C for the second time Reflux for 1.5 hours, filter to obtain the filtrate, combine the two filtrates and rotary evaporate to a volume of 896 ml, that is, the obtained.

Embodiment 3

[0040] Embodiment 3: pharmacological test

[0041] 1) Experimental animals

[0042] A. Rats: 108 Specific pathogen Free (SPF) grade male CD (SD) rats (Beijing Weitong Lihua Co., Ltd., animal certificate number: 11400700359419), in the SPF grade animal barrier system, The experimental rats were raised in stainless steel wire cages (500×350×200 mm), 6 rats per cage, and the quarantine period was 5-7 days. Healthy rats were selected for the experiment.

[0043] B. Model establishment: except the normal control group. Rats were intravenously anesthetized with pentobarbital, fixed on the rat board in a supine position, the neck hair was cut off, and the skin was disinfected with 75% alcohol + povidone iodine. The neck incision was separated layer by layer until the trachea was exposed. Under direct vision, a 1 ml syringe was used to puncture the space between the two cartilage rings, keeping the needle in the same direction as the airway, and a one-time rapid injection of bleomycin...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating lung diseases and its pharmaceutical use, including nightshade, lily, Prunella vulgaris, Fritillaria japonicus, Chonglou, Polygonatum, Radix Radix Scutellariae, Scutellaria barbata and Hedyotis diffusa, Prepared by water extraction or alcohol extraction, the composition has a therapeutic effect on lung diseases, especially those related to oxidation / antioxidation imbalance or inflammatory response, including elevated levels of HYP or MDA, or TGF‑β The abnormal expression of SOD and GSH, etc., or the reduction of SOD and GSH levels, etc., have been tested to improve the lung tissue of rats, and the anti-fibrosis effect is better than that of Qingfei Mixture and pirfenidone.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an active component of traditional Chinese medicine and its application in preparing medicine for treating lung diseases. Background technique [0002] Respiratory system diseases are mainly acute inflammation of the nose and pharynx, mostly caused by viruses, or allergies to smoking, mining, industrial waste gas, etc., which can lead to tracheobronchial inflammation and lung diseases, and in severe cases, pulmonary fibrosis, pulmonary edema, pulmonary embolism, etc. . With the development of urbanization, the population density is increasing day by day, and the personal work pressure continues to increase. Many people are in a state of sub-health and low immunity. The air pollution caused by industrial development makes respiratory diseases more and more common and serious. Especially with the epidemic pneumonia bacterial virus, the lung immune system is the first to be attacked. [0003...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P11/00A61P39/06
CPCA61K36/23A61K36/34A61K36/342A61K36/536A61K36/539A61K36/748A61K36/81A61K36/896A61K36/8966A61K36/8967A61K36/8969A61K2236/331A61K2236/333A61K2236/39A61P11/00A61P39/06A61K2300/00
Inventor 黄萍李清林张轶雯刘宇佳郑小卫潘宗富邹小舟
Owner ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
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