Functionally linked polypeptide, exosome drug delivery system that can specifically bind collagen and its application
A technology for connecting peptides and exosomes, which is used in the repair of spinal cord injury. It can specifically bind to collagen exosome drug delivery system and its construction field. It can solve the problem of limited exosome microspheres and exosome microspheres. It can reduce the rapid loss of balls, promote the recovery of behavioral functions, and promote maturity and functionalization.
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[0039] In view of the deficiencies in the prior art, the inventors of the present invention have, through long-term research and extensive practice, connected an exosome drug-carrying system with collagen-specific binding ability to a collagen scaffold. The technical solution, its implementation process and principle will be further explained as follows.
[0040] One aspect of the embodiments of the present invention provides a functionally linked polypeptide comprising a collagen-binding peptide sequence and an exosome-binding peptide sequence linked to the collagen-binding peptide sequence.
[0041]In some preferred embodiments, the functionally linked polypeptide has an exosome-binding peptide sequence (BP9) at one end that specifically binds to the surface of drug-loaded exosomes, and a collagen-binding peptide sequence (CBD) that specifically binds to the surface of collagen at the other end. Double binding function.
[0042] Further, the functional linking polypeptide (...
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