Compounds for use in the treatment of brain diseases

A brain tumor and compound technology, applied in the field of compounds used in brain tumor treatment, can solve problems such as obstacles and achieve the effect of increasing the drug delivery rate
CN112004534APending Publication Date: 2020-11-27UNIV DEGLI STUDI DI ROMA LA SAPIENZA +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
UNIV DEGLI STUDI DI ROMA LA SAPIENZA
Publication Date
2020-11-27

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Abstract

The present invention relates to a compound of formula (1): (1) or an analogue thereof or a pharmaceutically acceptable salt thereof, for use in the treatment of a brain tumor, wherein said compound is administered intranasally and relative pharmaceutical compositions.
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Description

technical field

[0001] The present invention relates to a method for rapidly and efficiently distributing a compound of formula (I), its analogue or a pharmaceutically acceptable salt thereof used alone or together with other compounds, and related pharmaceutical compositions:

[0002]

[0003] Specifically, these compounds achieve systemic circulation by intranasal administration. Rapid onset of beneficial effects of rapid treatment and / or prevention of brain tumors is then achieved. Background technique

[0004] Glioblastoma is the most widespread and aggressive tumor of the central nervous system (CNS), characterized by high levels of tumor cell invasion and proliferation, and high levels of inflammation and necrosis of nervous tissue (1). Although neurosurgery and the development of new drugs are ongoing, there are currently no effective treatments against the growth of this brain tumor, and patient death occurs within approximately twelve months of pathological diag...

Claims

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