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A method for preparing extracellular vesicles and its application

A cell and vesicle technology, applied in the field of extracellular vesicle preparation, can solve the problems of lack of pyroptosis application and transformation, and achieve the effect of precise targeted therapy, wide application channels, and strong immunogenicity

Active Publication Date: 2022-06-03
XUZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Pyroptosis is an important natural immune response of the body and plays an important role in fighting infection. However, the research on the application and transformation of pyroptosis is still lacking

Method used

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  • A method for preparing extracellular vesicles and its application
  • A method for preparing extracellular vesicles and its application
  • A method for preparing extracellular vesicles and its application

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Embodiment 3

[0049] The present invention establishes a cell pyroptosis model to induce cell pyroptosis, and prepares a diameter of 2-5 μm and contains cysteine

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Abstract

The invention discloses a method for preparing extracellular vesicles and its application, including establishing a cell pyroptosis model to induce pyroptosis in cells; pyroptotic bodies. The preparation method of pyroptotic bodies of the present invention is convenient to operate and low in production cost, and the obtained pyroptotic bodies have high purity, good activity, convenient storage, low toxic and side effects, and are conducive to continuous production; meanwhile, they have a wide range of applications and can not only be used as a method for detecting damaged parts. Specific markers, and can be used in immunotherapy as a tumor vaccine, so as to achieve precise targeted therapy of cancer and promote the development of tumor vaccines or drugs.

Description

Method for preparing extracellular vesicles and application thereof technical field The invention belongs to the technical field of extracellular vesicle preparation, in particular to a method for preparing extracellular vesicles and the same application. Background technique [0002] Pyroptosis, also known as cell inflammatory necrosis, is characterized by cell swelling and rounding, cell membrane rupture, and release of inflammatory factors. In recent years, studies have confirmed that various cells in the body can undergo pyroptosis, and pyroptosis will cause nuclear shrinkage and exocytosis of vesicles. into pyroptosis. Pyroptosis is an important innate immune response in the body and plays an important role in fighting infection. Previous studies on the application and translation of pyroptosis are still lacking. SUMMARY OF THE INVENTION [0004] The purpose of this section is to outline some aspects of embodiments of the invention and to briefly introduce som...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/071C12N5/09A61K35/42A61K35/44A61P35/00
CPCC12N5/069C12N5/0625C12N5/0693A61K35/42A61K35/44A61P35/00C12N2509/10C12N2501/90C12N2501/999
Inventor 张昊秦西淳周叶卿贾才力晁志祥秦昊刘修成
Owner XUZHOU MEDICAL UNIV
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