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Application of double-chamber double-input blood perfusion model in early diagnosis of liver cancer of FDG-18 pet

An early diagnosis, double-input technology, applied in the direction of radiological diagnostic equipment, diagnosis, application, etc., can solve problems such as model parameter differences

Inactive Publication Date: 2020-12-04
KUNMING UNIV OF SCI & TECH
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Problems solved by technology

[0003] The blood perfusion model of double compartment and double input has been proposed in the early stage, and has been verified in some fields such as early diagnosis of breast cancer; but only the difference in model parameters between lesions and normal tissues can be obtained; Atrioventricular double-input model used in the study of FDG-18 pet liver cancer

Method used

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  • Application of double-chamber double-input blood perfusion model in early diagnosis of liver cancer of FDG-18 pet
  • Application of double-chamber double-input blood perfusion model in early diagnosis of liver cancer of FDG-18 pet
  • Application of double-chamber double-input blood perfusion model in early diagnosis of liver cancer of FDG-18 pet

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Embodiment 1

[0014] Test material and method of the embodiment of the present invention: 17 routine patients have accepted PET / CT scanning and metabolic PET / CT scanning; Adopt ftig method to calculate hepatic artery blood flow (Fa), portal vein flow (Fv), total blood flow (F ), hepatic artery perfusion index (HPD), portal perfusion index (PP), volume of distribution (Ve), mean extracellular transit time (MTT) and ntaecllular uptake rate (K) and other perfusion parameters; metabolic PET / CT (SUVmax ), compared the perfusion parameters and maximum standardized uptake value (SUVmax) between HCCs and the surrounding liver; two reviewers evaluated the diagnostic value of perfusion PET / CT and metabolic PET / CT for HCC.

[0015] The patient information was provided by the Nanfang Pet Center of Nanfang Hospital, Southern Medical University, and written informed consent was obtained from all patients; this study was approved by the Academic Review Committee of the First People's Hospital of Yunnan Pro...

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Abstract

The invention discloses application of a double-chamber double-input blood perfusion model in early diagnosis of liver cancer of FDG-18 pet. The application comprises the following steps: calculatingperfusion parameters by adopting a fitting method, wherein the perfusion parameters comprise hepatic artery blood flow, portal vein blood flow, total blood flow, hepatic artery perfusion index, portalvein perfusion index, distribution volume, extracellular average transit time and intracellular uptake rate; generating hepatic artery blood flow, hepatic artery perfusion index, extracellular average transit time and intracellular uptake rate images by using software; comparing perfusion parameters of hepatocellular carcinoma tissues and surrounding liver tissues with a maximum standard uptake value based on metabolic PET / CT (suvmax); and evaluating the values of PET / CT perfusion imaging and metabolic PET / CT diagnosis of liver cancer by two reviewers. When a double-input double-chamber uptake model is adopted for analysis, the PET / CT perfusion parameters and images have good performance in the aspect of diagnosing hepatocellular carcinoma.

Description

technical field [0001] The invention relates to the application of a blood perfusion model with double atrioventricular and double input in the early diagnosis of liver cancer by FDG-18 pet, and belongs to the technical field of liver cancer diagnosis. Background technique [0002] Liver cancer refers to malignant tumors derived from hepatic cells and hepatic cholangiocytes. It is divided into two categories: primary and secondary. It is a common malignant tumor in my country. Symptoms of early liver cancer are usually non-specific, while symptoms of middle and advanced liver cancer are more common. Common clinical manifestations include pain in the liver area, abdominal distension, anorexia, fatigue, emaciation, progressive hepatomegaly or upper abdominal mass, etc.; some patients have low-grade fever , jaundice, diarrhea, upper gastrointestinal bleeding, etc.; liver cancer is predicted to be the sixth most common cancer. [0003] The blood perfusion model of double compar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/03G16H30/20G16H50/20
CPCA61B6/037A61B6/032A61B6/481A61B6/52G16H30/20G16H50/20
Inventor 贺建峰李柏桥王绍波季云海杨莎莎佘波徐东东鲁仁财王思丹王思宇
Owner KUNMING UNIV OF SCI & TECH
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