Application of D-leucine and chlorhexidine composition

A technology of leucine and chlorhexidine, which is applied in the field of medicine and health, can solve the problem of cariogenic streptococcus mutans not found in the combination of D-leucine and chlorhexidine, and achieve the goal of reducing adverse reactions and lowering the concentration of use Effect

Active Publication Date: 2020-12-04
HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV
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AI Technical Summary

Problems solved by technology

However, there is no report on the related technology of D-leucine and chlorhexidine composition in inhibiting cariogenic Streptococcus mutans

Method used

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  • Application of D-leucine and chlorhexidine composition
  • Application of D-leucine and chlorhexidine composition
  • Application of D-leucine and chlorhexidine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Example D-leucine enhances the bactericidal effect of chlorhexidine on cariogenic mutans Streptococcus related experimental research.

[0026] 1. Antibacterial experiment.

[0027] 1. Grouping of antibacterial experiments.

[0028] The first group: no treatment group (control group).

[0029] The second group: 100ppm D-leucine group.

[0030] The third group: 1ppm chlorhexidine group.

[0031] The fourth group: 1 ppm chlorhexidine + 100 ppm D-leucine group.

[0032] The fifth group: 10ppm chlorhexidine group.

[0033] 2. Experimental content.

[0034] Streptococcus mutans was used in this study. Before the experiment, the bacteria were extracted from frozen glycerol and cultured in brain heart infusion broth (BHI, pH = 7.0) agar medium (AOBOX, China) at 37°C under anaerobic conditions (90% N 2 , 10% CO 2 ) 72h. The BHI medium was sterilized at 121°C for 15 minutes, and the colony of Streptococcus mutans was transferred to 50ml of BHI liquid medium, and cultured...

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Abstract

The invention belongs to the technical field of medicine and health, and relates to application of a D-leucine and chlorhexidine composition, in particular to application of the D-leucine and chlorhexidine composition to preparation of a medicine for preventing or treating caries. Experimental research proves that the mechanism of D-leucine for enhancing the bactericidal effect of chlorhexidine oncariogenic streptococcus mutans is that D-leucine converts streptococcus mutans in a biofilm state into floating streptococcus mutans in a dispersed state, so that streptococcus mutans is easier to kill, thereby enhancing the killing effect of chlorhexidine on streptococcus mutans; the D-leucine and chlorhexidine composition is prepared by adding the green compound D-leucine into the oral bactericide chlorhexidine, so that the cariogenic streptococcus mutans biofilm is killed, the use concentration of the chlorhexidine is greatly reduced, the adverse reaction of clinical application of the chlorhexidine is reduced, the same sterilization effect is achieved, and the composition has a clinical conversion prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine and health, and relates to the application of D-leucine and chlorhexidine composition, in particular to the application of D-leucine and chlorhexidine composition in preparing medicines for preventing or treating dental caries. Background technique [0002] Dental caries is the number one disease of the oral cavity. Streptococcus mutans is considered to be the main pathogenic microorganism of the disease. It mainly causes dental caries through the formation of dental plaque biofilm on the tooth surface. In severe cases, it can develop into pulp disease and root apex week sickness. Caries can only occur and develop in the presence of dental plaque biofilm, so effective removal and control of dental plaque biofilm is the key to the prevention and treatment of dental caries. In the clinic, methods to reduce the number of Streptococcus mutans include mechanical removal and mouthwash. During orthodo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/155A61P1/02A61P31/02
CPCA61K31/155A61K31/198A61P1/02A61P31/02A61K2300/00
Inventor 刘奕徐大可闫昱文郑博文郑颖吴昊鹏刘艺张明月安娜杨晓丰赵阳
Owner HOSPITAL OF STOMATOLOGY CHINA MEDICAL UNIV
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