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Application of Rhus chinensis Mill. fruit in preparation of medicine for treating or preventing non-alcoholic fatty liver disease

A non-alcoholic, salt-skinned wood technology, applied in the application field of medicine, can solve the problems such as no patent literature report, achieve the effect of inhibiting deposition and liver cell damage, and high safety

Inactive Publication Date: 2020-12-15
KUNMING AROMATIC PLANT BIOTECHNOLOGY DEV CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no patent literature reports on the relevant research on the prevention and treatment of NAFLD by sarcocarp at home and abroad

Method used

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  • Application of Rhus chinensis Mill. fruit in preparation of medicine for treating or preventing non-alcoholic fatty liver disease
  • Application of Rhus chinensis Mill. fruit in preparation of medicine for treating or preventing non-alcoholic fatty liver disease
  • Application of Rhus chinensis Mill. fruit in preparation of medicine for treating or preventing non-alcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The water extract of embodiment 1 Salmonella fruit

[0024] Preparation method: Take the fruit of Saltwort, add water according to the ratio of material to liquid at 1:20, and boil for 1 hour. After boiling, it is centrifuged while it is hot at a speed of 4000r / min, and the supernatant is subjected to suction filtration, and the sample after suction filtration is concentrated, and finally freeze-dried to obtain the water extract of the fruit of Salmonella.

Embodiment 2

[0025] The ethanol extract of embodiment 2 Salmonella fruit

[0026] Preparation method: take the fruit of Salicopus chinensis, add 80% ethanol solution (volume percentage) according to the ratio of material to liquid at 1:5, ultrasonically extract, the extraction temperature is 25°C, the extraction time is 30min, the filter residue is extracted again, and then 4000r / min Centrifuge, take the supernatant, concentrate and freeze-dry, and obtain the alcohol extract of the fruit of Salmonella.

Embodiment 3

[0027] The tablet of embodiment 3 Salmonella fruit

[0028] Preparation method: take the fruit of Salicopus chinensis, add 80% ethanol solution (volume percentage) according to the ratio of material to liquid at 1:5, ultrasonically extract, the extraction temperature is 25°C, the extraction time is 30min, the filter residue is extracted again, and then 4000r / min Centrifuge, take the supernatant, concentrate and freeze-dry, and obtain the alcohol extract of the fruit of Salmonella. The alcoholic extract of the fruit of Salmonella chinensis is added into conventional excipients to make clinically acceptable tablets according to the conventional process.

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PUM

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Abstract

The invention relates to the field of a new medical purpose of chemical substances, in particular to application of Rhus chinensis Mill. fruits in preparation of a medicine for treating or preventingthe non-alcoholic fatty liver disease. Researches found that different extracts of the Rhus chinensis Mill. fruits can effectively inhibit lipid particle deposition in the liver of a NAFLD model rat and liver cell injuries under a low dosage, and therefore, the extracts of the Rhus chinensis Mill. fruits can serve as a candidate medicine for treating the non-alcoholic fatty liver disease, especially simple fatty liver, fatty liver hepatitis, simple fatty liver merged with glycolipid regulation injuries, fatty hepatitis merged with glycolipid regulation injuries, fatty liver hepatitis liver cirrhosis and fatty hepatitis associated liver cancer. In addition, the medicine raw materials of the invention are from natural edible plant raw materials, and therefore, safety is high.

Description

technical field [0001] The present invention relates to the field of new medical application of chemical substances, in particular to the application of a kind of fruit of Salmonella in the preparation of medicine for treating or preventing non-alcoholic fatty liver. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) refers to a clinicopathological syndrome characterized by excessive fat deposition in liver cells caused by alcohol and other definite liver damage factors. It is associated with insulin resistance and genetic Susceptibility closely related to acquired metabolic stress-induced liver injury. Including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH) and related cirrhosis. With the global prevalence of obesity and related metabolic syndrome, NAFLD has become an important cause of chronic liver disease in developed countries such as Europe and the United States and in wealthy areas of my country. The prevalence of NAFLD in ordinar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/22A61P1/16A61P3/00A61P3/04A61P5/50A61P35/00A23L33/105
CPCA61K36/22A61P1/16A61P3/00A61P3/04A61P5/50A61P35/00A23L33/105A23V2002/00A23V2200/32A23V2200/308A23V2200/30A23V2200/332
Inventor 蔡圣宝吴子桓王春丽刘晓靖马倩
Owner KUNMING AROMATIC PLANT BIOTECHNOLOGY DEV CO LTD
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