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A method for automated non-invasive measurement of sperm motility and morphology and automated selection of a sperm with high DNA integrity

A technology of morphology and morphological characteristics, applied in biochemical equipment and methods, measurement devices, bioreactors/fermenters for specific purposes, etc., which can solve undisclosed automatic switching, undisclosed methods of sperm morphology measurement, etc. question

Pending Publication Date: 2020-12-18
THE GOVERNING COUNCIL OF THE UNIV OF TORONTO
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The method used for sperm morphology measurements was also unpublished in our previous work
Furthermore, sperm tracking and manipulation were performed at the same microscope magnification, and automatic switching of microscope magnification for motility and morphology measurements on the same sperm was not disclosed

Method used

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  • A method for automated non-invasive measurement of sperm motility and morphology and automated selection of a sperm with high DNA integrity
  • A method for automated non-invasive measurement of sperm motility and morphology and automated selection of a sperm with high DNA integrity
  • A method for automated non-invasive measurement of sperm motility and morphology and automated selection of a sperm with high DNA integrity

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[0063] definition

[0064] Unless otherwise stated, the following definitions apply to all aspects and embodiments of this application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Also, the use of "or" includes "and" and vice versa except in the claims unless stated otherwise. Non-limiting terms are not to be construed as limiting unless expressly stated or the context clearly dictates otherwise (eg, "including," "having," and "comprising" generally mean "including but not limited to"). Included in the claims, singular forms such as "a", "an" and "the" include plural referents unless expressly stated otherwise. All relevant references (including patents, patent applications, government publications, government regulations, and scholarly literature) are described in detail below and are incorporated by reference in their entirety.

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Abstract

A method of automated measurement of motility and morphology parameters of the same single motile sperm. Automated motility and morphology measurements of the same single sperm are performed under different microscope magnifications. The same single motile sperm is automatically positioned and kept inside microscope field of view and in focus after magnification switch. A method of automated non-invasive measurement of sperm morphology parameters under high magnification of imaging. Sperm morphology parameters including subcellular structures are automatically measured without invasive samplestaining. A method of automatically selecting sperms with normal motility and morphology and DNA integrity for infertility treatment.

Description

technical field [0001] The present invention relates to methods for automatic motility and morphology measurements of the same single motile sperm at different microscope magnifications and automatic selection of sperm with normal motility and morphology. Background technique [0002] The World Health Organization (WHO) reports that 48.5 million couples worldwide suffer from infertility, and many of these couples seek in vitro fertilization (IVF) for treatment. There are currently approximately 3,000 IVF clinics worldwide, including 458 in the United States alone, and the number is growing rapidly. Measurements of sperm motility and morphology are important for IVF, with a wide range of applications such as male infertility diagnosis and selection of sperm for IVF treatments such as intracytoplasmic sperm injection (ICSI). [0003] Sperm can move rapidly out of the microscope field due to their rapid movement (eg, >25 μm / s). Therefore, sperm motility measurements requir...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/10C12M1/34C12Q1/02
CPCG01N15/10G01N2015/1006C12N5/0612C12N5/061G06V20/698G06V10/245G01N2015/1027G01N15/1429G01N2015/1497G02B21/025G02B21/241G02B21/26G02B21/367G06T7/0014G06T2207/10056G06T2207/20036G06T2207/20061G06T2207/30024G01N15/1433
Inventor 孙钰戴昌盛张焯然
Owner THE GOVERNING COUNCIL OF THE UNIV OF TORONTO
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