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Cosmetic containing tetraacetylglucoside modified phloretin and preparation method of cosmetic

A technology of tetraacetylglucose and pentaacetylglucose, which is applied in the field of phloretin cosmetics and its preparation, can solve the problems of limiting the application diversity of phloretin, low absorption and utilization rate of phloretin, and poor water solubility of phloretin. Achieve the effect of improving water solubility and skin absorption efficiency, excellent anti-oxidation

Pending Publication Date: 2020-12-25
青岛姿之妍化妆品科技有限责任公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, gel preparations limit the application versatility of phloretin
[0005] In addition, the water solubility of phloretin is poor, and the absorption and utilization rate of phloretin itself by human skin is relatively low. The action time on the surface of human skin, but this cannot fundamentally improve the absorption efficiency of human skin for phloretin

Method used

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  • Cosmetic containing tetraacetylglucoside modified phloretin and preparation method of cosmetic
  • Cosmetic containing tetraacetylglucoside modified phloretin and preparation method of cosmetic
  • Cosmetic containing tetraacetylglucoside modified phloretin and preparation method of cosmetic

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Embodiment Construction

[0022] The contents of the present invention will be set forth below through specific examples, but these contents are not the entire contents of the present invention. First, the phloretin modified by tetraacetylglucoside of the present invention is first obtained according to the following preparation method:

[0023] (1), glucose monohydrate is added in the acetic anhydride of 3 times of molar quantity, the triethylamine of 5 times of molar quantity is added dropwise under the condition of ice-water bath, after reacting for 2 hours, add sufficient amount of water to separate out the product, filter the filter cake with water Vacuum-dry after washing to obtain pentaacetylglucose; dissolve the dried pentaacetylglucose in dichloromethane, and add hydrobromic acid with 3 times the molar amount of pentaacetylglucose dropwise at room temperature, wherein the hydrobromic acid has a mass concentration of 30%. The acetic acid solution of hydrobromic acid was provided, and after reac...

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Abstract

The invention provides a brand-new phloretin derivative preparation method. The method comprises the steps of carrying out modified grafting on hydroxyl in p-hydroxyphenylpropionic acid in a phloretinsynthesis raw material in advance, and then carrying out a synthesis reaction with phloroglucinol to obtain a corresponding phloretin derivative, namely tetraacetylglucoside modified phloretin. The derivative not only retains the oxidation resistance and inflammation resistance of phloretin, but also has good water solubility and skin absorption efficiency, so that the obtained phloretin derivative can be widely applied to various forms of cosmetic products and has excellent oxidation resistance and inflammation resistance.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to cosmetics containing tetraacetylglucoside-modified phloretin and a preparation method thereof. Background technique [0002] Cosmetics refer to products that are applied to the surface of the human body by smearing or other similar methods to achieve the effects of cleaning, maintaining, and beautifying the surface. At present, there are many kinds of cosmetics on the market, among which, the cosmetics for relieving skin inflammation, anti-oxidation and anti-aging are most popular among women. [0003] Phloretin, namely 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone, is a natural flavonoid compound, mainly distributed in the pericarp and root bark of juicy fruits such as apples and pears, and various vegetable juices. Phloretin has the functions of whitening and acne removal, anti-oxidation and anti-inflammation, and has been widely added to various cosmetics. However, when phloret...

Claims

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Application Information

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IPC IPC(8): C07H15/203C07H1/00A61K8/60A61P17/00A61P17/18A61P29/00A61Q19/00A61Q19/08
CPCA61K8/602A61Q19/00A61Q19/08A61P17/00A61P17/18A61P29/00C07H1/00C07H15/203
Inventor 蔺会杰
Owner 青岛姿之妍化妆品科技有限责任公司
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