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Transcriptome and DNA methylation data correlation analysis method and system

An analysis method and association analysis technology, applied in the fields of transcriptomics and DNA methylomics, can solve the problem of incomplete analysis of single omics data, and achieve the effect of comprehensive analysis content

Pending Publication Date: 2021-01-08
广州基迪奥科技服务有限公司
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Problems solved by technology

[0005] In order to overcome the deficiencies in the prior art mentioned above, the purpose of the present invention is to provide a method and system for correlation analysis of transcriptome and DNA methylation data, so as to solve the problem of incomplete analysis of single omics data in the prior art

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  • Transcriptome and DNA methylation data correlation analysis method and system
  • Transcriptome and DNA methylation data correlation analysis method and system
  • Transcriptome and DNA methylation data correlation analysis method and system

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Embodiment Construction

[0032] The implementation of the present invention is described below through specific examples and in conjunction with the accompanying drawings, and those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific examples, and various modifications and changes can be made to the details in this specification based on different viewpoints and applications without departing from the spirit of the present invention.

[0033] After analysis, it was found that based on the analysis of two-group (transcriptomics and DNA methylation) data association analysis, the problem of incomplete single-omics analysis can be overcome, and the relationship between RNA expression and DNA methylation modification in the sample can be obtained. relevance. Therefore, the present invention proposes a method and system for co...

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Abstract

The invention discloses a transcriptome and DNA methylation data correlation analysis method and system, and the method comprises the following steps: S1, carrying out the transcriptome sequencing ofa sample, carrying out the biological information analysis of the data obtained through sequencing, and obtaining a differential expression gene; S2, performing DNA methylation sequencing on the sample, and performing biological information analysis on data obtained by sequencing to obtain a differential methylation region; and S3, carrying out correlation analysis on the obtained differential expression gene and the differential methylation region. Through the method and the device, the problems of one-sidedness and partial data unreliability of data of single omics sequencing in the prior art are solved; meanwhile, the correlation between RNA expression and DNA methylation modification in the sample can be obtained through two-omics integration analysis, and the analysis content is morecomprehensive.

Description

technical field [0001] The invention relates to the technical fields of transcriptomics and DNA methylation, in particular to a method and system for correlation analysis of transcriptomics and DNA methylation data. Background technique [0002] DNA methylation is a very important epigenetic modification and one of the main mechanisms to regulate gene expression during cell differentiation and development. It is involved in the formation of heterochromatin, the silencing of transposons, the regulation of gene expression and the imprinting of genes happened. It has a wide range of applications, including: (1) the growth and development process, especially the period of drastic changes in DNA methylation modification such as seed and embryonic development; (2) the change of epigenetic modification in the process of disease resistance and stress resistance; (3) Speculate on the impact of epigenetic modification on disease susceptibility genes and pathogenic mechanisms. [000...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/00
CPCG16B20/00
Inventor 夏昊强周煌凯高川
Owner 广州基迪奥科技服务有限公司
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