Improved continuous microparticle manufacture
A technology of microparticles and liquid dispersions, which is used in medical preparations containing active ingredients, drug combinations, organic active ingredients, etc., and can solve the problems of low drug loading of microparticles, insufficient control of drug release curves, and particle instability. The effect of achieving high drug loading levels, reducing residence time, and reducing the incidence of leaching
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0312] Example 1: Synthesis of risperidone-containing microparticles using a plug flow reactor and TWHFTFF
[0313]By mixing 180 mg / mL poly(lactic-co-glycolic acid) (PLGA) / monomethoxypolyethylene glycol-PLGA (mPEG) (99:1 mixture) in dichloromethane (DCM) in a dispersion phase tank The dispersed phase was prepared with a solution of 50.1 mg / mL risperidone in dimethyl sulfoxide (DMSO) until a homogeneous solution was obtained. The continuous phase was prepared from 0.25% PVA and water in a continuous phase tank. The dispersed and continuous phases are fed into the in-line mixer through their respective conduits. The dispersed phase was passed through a hydrophobic PTFE filter and fed into an inline mixer via a cannula at a rate of 20 mL / min. The continuous phase was passed through a hydrophilic PVDF filter (0.20 μιη) and fed into an inline mixer at a rate of 2000 mL / min via a cannula. An impeller rotating at 4000 rpm in the in-line mixer provided thorough mixing of the disper...
Embodiment 2
[0314] Example 2: Synthesis of risperidone-containing microparticles using continuous centrifugation
[0315] By mixing 180 mg / mL poly(lactic-co-glycolic acid) (PLGA) / monomethoxypolyethylene glycol-PLGA (mPEG) (99:1 mixture) in dichloromethane (DCM) in a dispersion phase tank The dispersed phase was prepared with a solution of 50.1 mg / mL risperidone in dimethyl sulfoxide (DMSO) until a homogeneous solution was obtained. The continuous phase was prepared from 0.25% PVA and water in a continuous phase tank. The dispersed and continuous phases are fed into the in-line mixer through their respective conduits. The dispersed phase was passed through a hydrophobic PTFE filter and fed into an inline mixer via a cannula at a rate of 20 mL / min. The continuous phase was passed through a hydrophilic PVDF filter (0.20 μιη) and fed into an inline mixer at a rate of 2000 mL / min via a cannula. An impeller rotating at 4000 rpm in the in-line mixer provided thorough mixing of the dispersed a...
Embodiment 3
[0316] Example 3: Continuous centrifugation as a separation process to remove small particles
[0317] Continuous centrifugation is introduced as a separation process in the production of surface-treated particles (STP) in order to remove small particles and to wash and concentrate the particles. The process continuously separates small particles from larger particles by centrifugation and discharges the retained larger particles at the end of the cycle. Serial centrifugation was performed using a UniFuge Pilot separation system from Pneumatic Scale Angelus. Figure 1M and Figure 1N Centrifuge 1, Centrifuge 2, Centrifuge 3 and Centrifuge 4 are involved.
[0318] For batches of 200g scale, centrifuge 1 was performed simultaneously with the homogenization step for approximately 2 hours: as the dispersed phase (DP) and continuous phase (CP) were mixed in the homogenizer, the resulting liquid from the homogenizer flowed into into a glass container. The volume of the container...
PUM
| Property | Measurement | Unit |
|---|---|---|
| size | aaaaa | aaaaa |
| size | aaaaa | aaaaa |
| diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More