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Desonide nano-emulsion gel composition and preparation method thereof

A technology of gel composition and nanoemulsion, which is applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of poor solubility, poor therapeutic effect, short maintenance time, etc., achieve strong penetration ability, improve adhesion and The effect of spreadability and good stability

Pending Publication Date: 2021-01-26
BRIGHT FUTURE PHARMA LAB LTD (CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of this application is to provide a desonide nanoemulsion gel composition and its preparation method, aiming to solve the problems of poor solubility of products containing desonide in the prior art, resulting in shorter maintenance time and poor therapeutic effect.

Method used

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  • Desonide nano-emulsion gel composition and preparation method thereof
  • Desonide nano-emulsion gel composition and preparation method thereof
  • Desonide nano-emulsion gel composition and preparation method thereof

Examples

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preparation example Construction

[0072] The second aspect of the embodiment of the present application provides a method for preparing a desonide nanoemulsion gel composition, comprising the following steps:

[0073] S01. Weigh each raw and auxiliary material according to the components contained in the desonide nanoemulsion gel composition and the prescription amount;

[0074] S02. Mixing desonide, oil phase components, oil-soluble emulsifier and co-emulsifier to obtain oil phase raw material; mixing water-soluble emulsifier and partially purified water to obtain water phase raw material;

[0075] S03. Under the action of magnetic stirring, drop the oil phase raw material into the water phase raw material, perform preliminary emulsification treatment to obtain coarse milk, and homogenize the coarse milk to obtain desonide nanoemulsion;

[0076] S04. Mix the gel matrix and part of the water for the first dissolution treatment to obtain the gel mixture, and perform the second dissolution treatment for the pres...

Embodiment 1

[0095] Desonide nanoemulsion gel composition and preparation method thereof

[0096] The raw material selection and addition amount of the desonide nanoemulsion gel composition are shown in Table 1 below:

[0097] Table 1

[0098]

[0099]

[0100] Preparation:

[0101] According to the contained components and prescription quantity contained in the desonide nanoemulsion gel composition provided in Table 1 in Example 1, each raw and auxiliary material is weighed;

[0102] Desonide was dissolved in 2,6-dibutylhydroxytoluene, palm oil, triacetin, and oleic acid to obtain the oil phase components, and then Tween 20, poloxamer 407, diethylene glycol mono Ethyl ether is dissolved in purified water to obtain a water phase raw material;

[0103] Under the action of magnetic stirring with a rotation speed of 500rpm, the oil phase raw material was added dropwise to the water phase raw material, and the initial emulsification treatment was carried out at a speed of 12000rpm for...

Embodiment 2

[0107] The raw material selection and addition amount of the desonide nanoemulsion gel composition are shown in Table 2 below:

[0108] Table 2

[0109]

[0110]

[0111] Preparation:

[0112] According to the contained components and prescription quantity contained in the desonide nanoemulsion gel composition provided in Table 2 in Example 2, each raw and auxiliary material is weighed;

[0113] Dissolve desonide in eucalyptus oil, glyceryl triacetate, oleic acid, and Span 80 to obtain the oil phase components, and then dissolve Tween 80, poloxamer 407, and diethylene glycol monoethyl ether in the purified Water phase raw material is obtained in water;

[0114]Under the action of magnetic stirring with a rotation speed of 500rpm, the oil phase raw material was added dropwise to the water phase raw material, and the initial emulsification treatment was carried out at a speed of 12000rpm for 8min to obtain a rough milk, and the rough milk was homogenized to obtain a drop...

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Abstract

The invention provides a desonide nano-emulsion gel composition and a preparation method thereof. The desonide nano-emulsion gel composition comprises the following components in percentage by weight:0.05%-1.0% of desonide, 5%-20% of an oil phase component, 0.1%-10% of an emulsifier, 0.5%-9% of a co-emulsifier, 0.5%-10% of a wetting agent, 0.5%-3% of a gel matrix, 3%-10% of a humectant, 0.001%-0.1% of a metal ion chelating agent, 0.001%-0.2% of a preservative, 0.01%-0.5% of an antioxidant, and 89.388% to 90.338% of water. The oil-in-water desonide nano-emulsion gel composition provided by theinvention has good stability, adhesion and spreadability, can improve the penetration capacity and targeting effect of the desonide on the cuticle of the skin and improve the transdermal absorption of the desonide, and has strong penetration capacity, viscosity suitable for local administration and long drug release time, and the treatment effect of the desonide is improved.

Description

technical field [0001] The application belongs to the technical field of pharmaceutical preparations, in particular to a desonide nanoemulsion gel composition and a preparation method thereof. Background technique [0002] Dermatitis refers to a general term for skin inflammatory diseases caused by various internal and external infections or non-infectious factors. It is not an independent disease. Its etiology and clinical manifestations are complex and diverse, and recurrent, making clinical treatment difficult. At present, most views believe that dermatitis generally refers to inflammation of the skin, such as contact sensitization, skin infection, etc. In the chapter of dermatitis and eczema in the International Classification of Diseases (ICD)-10, it includes contact dermatitis, atopic dermatitis, Neurodermatitis and more than 20 kinds of diseases. Clinically, a specific dermatitis is often defined as certain dermatitis according to the etiology, site of disease or oth...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/107A61K31/58A61K47/44A61K47/14A61K47/12A61K47/22A61K47/26A61K47/10A61K47/32A61K47/18A61P17/00A61P29/00
CPCA61K9/06A61K9/1075A61K9/0014A61K31/58A61K47/44A61K47/14A61K47/12A61K47/22A61K47/26A61K47/10A61K47/32A61K47/183A61P17/00A61P29/00Y02A50/30
Inventor 马秋燕拉吉卜·萨卡吴涛林华庆
Owner BRIGHT FUTURE PHARMA LAB LTD (CN)
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