Application of bortezomib and preparation of bortezomib to preparation of medicine for treating choroidal neovascularization related diseases and preparation method of eye drops

A bortezomib and new blood vessel technology, applied in the field of ophthalmology, can solve the problems of retinal and choroidal atrophy, large side effects, etc., and achieve the effect of small side effects and good curative effect.

Pending Publication Date: 2021-01-26
WENZHOU MEDICAL UNIV
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Problems solved by technology

Anti-VEGF (vascular endothelial cell growth factor) antibody is currently the most important treatme

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  • Application of bortezomib and preparation of bortezomib to preparation of medicine for treating choroidal neovascularization related diseases and preparation method of eye drops
  • Application of bortezomib and preparation of bortezomib to preparation of medicine for treating choroidal neovascularization related diseases and preparation method of eye drops
  • Application of bortezomib and preparation of bortezomib to preparation of medicine for treating choroidal neovascularization related diseases and preparation method of eye drops

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[0020] Combine now figure 1 , figure 2 , image 3 , Figure 4 , Figure 5 , Image 6 , Figure 7 , Figure 8 The present invention is further described.

[0021] The materials used in the present invention can be obtained commercially or by conventional methods in the art.

[0022] Laser-induced CNV model and choroidal spread

[0023] CNV models were modeled using the Micron IV system (Phoenix Research Laboratories, Pleasanton, CA), and only eyes with bubbles at the injured site were selected for analysis. Krypton red laser (laser interval 0.05 s, duration 0.07 s, power 240 mW), laser spots evenly distributed around the optic disc, four laser spots per retina. On the second day after laser injury, the mice were randomly divided into intravitreal injection of saline (1.5 µL), intravitreal injection of bortezomib (15, 30, 45 pmol, 1.5 µL), anti-mouse VEGF ((0.3) µg, 1.5 µL). On the seventh day after laser photocoagulation, the choroid was fixed and spread. The forme...

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Abstract

The invention discloses application of bortezomib and preparation of bortezomib to preparation of a medicine for treating choroidal neovascularization related diseases and a preparation method of eyedrops. A protease complex inhibitor bortezomib is injected into a vitreous cavity or bortezomib eye drops are used on the ocular surface, the bortezomib and the preparation of bortezomib can be used for treating choroidal neovascularization related fundus diseases such as treatment of wet age-related macular degeneration, the side effect is small, and the curative effect is good.

Description

technical field [0001] The invention relates to the technical field of ophthalmology, in particular to the application of bortezomib and preparations thereof in the preparation of medicines for treating choroidal neovascularization-related diseases and the preparation method of eye drops. Background technique [0002] Age-related macular degeneration (AMD) is one of the main causes of visual impairment and blindness in the elderly, among which wet age-related macular degeneration is one of the important blinding factors, and the characteristic pathological changes are Choroidal neovascularization (CNV). Anti-VEGF (vascular endothelial cell growth factor) antibody is currently the most important treatment method, but its side effects are large, and long-term use can cause retinal and choroidal atrophy. Therefore, it is imperative to study therapeutic methods with few side effects and good curative effect. Contents of the invention [0003] In order to solve the technical ...

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Application Information

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IPC IPC(8): A61K38/05A61K9/08A61K47/20A61P9/10A61P27/02
CPCA61K38/05A61K9/08A61K9/0048A61K47/20A61P27/02A61P9/10
Inventor 吴圣洲刘依美冯美玲
Owner WENZHOU MEDICAL UNIV
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