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Preparation method of 5-hydroxytryptamine hydrochloride

A technology of hydroxytryptamine hydrochloride and oxindole, which is applied in the field of preparation of 5-hydroxytryptamine hydrochloride, can solve the problems of inconvenient industrial production, high cost, and low yield, and achieve good product quality and low cost. Low, high yield effect

Active Publication Date: 2021-02-02
南京法恩化学有限公司
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Problems solved by technology

[0003] (1) Bioorganic & Medicinal Chemistry Letters 20 (2010) 157-160 reported a method for synthesizing 5-hydroxytryptamine hydrochloride, the route is as shown in the accompanying drawing figure 1 As shown, the problem that this method exists is that raw material is not easy to get, and yield is low, and cost is high
[0004] (2) Tetrahedron 72 (2016) 2233-2238 reported a method for synthesizing 5-hydroxytryptamine hydrochloride, the route is as shown in the accompanying drawing figure 2 As shown, the problem that this method exists is to use the catalyst that is expensive and difficult to obtain, and the cost is high, and it is not convenient for industrialized production

Method used

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  • Preparation method of 5-hydroxytryptamine hydrochloride
  • Preparation method of 5-hydroxytryptamine hydrochloride
  • Preparation method of 5-hydroxytryptamine hydrochloride

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Embodiment Construction

[0022] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention.

[0023] refer to Figure 1-3 , a preparation method of 5-hydroxytryptamine hydrochloride, comprising the following steps:

[0024] S1: Add a solvent to the reaction flask, add 5-hydroxyindole, add nitroethylene, heat up the reaction, and track it in the central control; after the reaction is completed, concentrate, cool down and crystallize, filter, and dry the filter cake to obtain intermediate 1;

[0025] S2: Add the solvent into the autoclave, add intermediate 1, add the catalyst, replace the nitrogen with hydrogen, heat up the reaction, and track it in the central control; after the reaction is completed, press filter, and the filtrate is concentrated to dryness; ...

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Abstract

The invention discloses a preparation method of 5-hydroxytryptamine hydrochloride, and particularly relates to a method for efficiently synthesizing the 5-hydroxytryptamine hydrochloride by taking 5-hydroxyindole and nitroethylene as raw materials through addition reaction and reduction reaction. The preparation method of the 5-hydroxytryptamine hydrochloride provided by the invention is a preparation method which is high in yield, low in cost, less in three wastes, good in product purity and suitable for industrialization.

Description

technical field [0001] The invention specifically relates to the technical field of preparation of chemical components, in particular to a preparation method of 5-hydroxytryptamine hydrochloride. Background technique [0002] Serotonin (also known as serotonin or 5-HT) is a naturally occurring substance that acts as a neurotransmitter to carry signals throughout neurons. In the brain, serotonin helps regulate mood and memory, and serotonin also controls the body's sleep, sexual function, bone health and blood clotting. Serotonin has received more and more attention in the fields of medicine and health products. [0003] (1) Bioorganic & Medicinal Chemistry Letters 20 (2010) 157-160 reported a method for synthesizing 5-hydroxytryptamine hydrochloride, the route is as shown in the accompanying drawing figure 1 Shown, the problem that this method exists is that raw material is difficult to obtain, and yield is low, and cost is high. [0004] (2) Tetrahedron 72 (2016) 2233-22...

Claims

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Application Information

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IPC IPC(8): C07D209/16
CPCC07D209/16
Inventor 王坤鹏
Owner 南京法恩化学有限公司
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